{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T07:06:23Z","timestamp":1778310383521,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T00:00:00Z","timestamp":1702080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Stress has been considered as a potential trigger for hair loss through the neuroendocrine\u2010hair follicle (HF) axis. Neurotensin (NTS), a neuropeptide, is known to be dysregulated in the inflammatory\u2010associated skin diseases. However, the precise role of NTS in stress\u2010induced hair loss is unclear. To investigate the function and potential mechanisms of NTS in stress\u2010induced hair growth inhibition, we initially detected the expression of neurotensin receptor (\n                    <jats:italic>Ntsr<\/jats:italic>\n                    ) and NTS in the skin tissues of stressed mice by RNA\u2010sequencing and ELISA. We found chronic restraint stress (CRS) significantly decreased the expression of both NTS and\n                    <jats:italic>Ntsr<\/jats:italic>\n                    in the skin tissues of mice. Intracutaneous injection of NTS effectively counteracted CRS\u2010induced inhibition of hair growth in mice. Furthermore, NTS regulated a total of 1093 genes expression in human dermal papilla cells (HDPC), with 591 genes being up\u2010regulated and 502 genes being down\u2010regulated. GO analysis showed DNA replication, cell cycle, integral component of plasma membrane and angiogenesis\u2010associated genes were significantly regulated by NTS. KEGG enrichment demonstrated that NTS also regulated genes related to the Hippo signalling pathway, axon guidance, cytokine\u2013cytokine receptor interaction and Wnt signalling pathway in HDPC. Our results not only uncovered the potential effects of NTS on stress\u2010induced hair growth inhibition but also provided an understanding of the mechanisms at the gene transcriptional level.\n                  <\/jats:p>","DOI":"10.1111\/exd.14990","type":"journal-article","created":{"date-parts":[[2023,12,10]],"date-time":"2023-12-10T01:30:01Z","timestamp":1702171801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neurotensin counteracts hair growth inhibition induced by chronic restraint stress"],"prefix":"10.1111","volume":"33","author":[{"given":"Lingjing","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Hangzhou Children's Hospital  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Dermatology Yuyao People's Hospital  Ningbo China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Department of Dermatology Affiliated Huzhou Hospital, Zhejiang University School of Medicine  Huzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-6822","authenticated-orcid":false,"given":"Xuewen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Sir Run Run Shaw Hospital, Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenying","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology and 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