{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:10:54Z","timestamp":1789722654571,"version":"4.0.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alopecia areata (AA) is a non\u2010scarring autoimmune hair loss of the scalp or body. While an early onset is considered a primary factor for poor prognosis, children with early\u2010onset AA show varied responses to treatment. This study aimed to describe the clinical characteristics and assess the prognostic factors of early\u2010onset AA in children. We performed a retrospective study of AA patients aged &lt;10\u2009years who visited our dermatologic clinic between January 2013 and December 2020, with a follow\u2010up period &gt;12 months. A clinical review of medical records, photographs, and telephonic interviews was performed. Treatment efficacy was assessed based on the degree of hair regrowth at a 12\u2010month follow\u2010up. Of 162 patients treated with topical corticosteroids, alone or in combination with other modalities, 57.4% showed &gt;50% hair regrowth. On comparing the good and poor treatment response groups, no significant differences were observed in the presence of known prognostic factors, except for personal atopic history. In addition, patients aged &lt;4 years at onset responded significantly better than older patients (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0127). There is a possibility that the patients with early\u2010onset AA, especially those aged &lt;4 years, demonstrate good treatment response. Further studies on long\u2010term prognosis are required.\n                  <\/jats:p>","DOI":"10.1111\/exd.14991","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T01:54:30Z","timestamp":1703210070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A clinical investigation of\n                    <scp>early\u2010onset<\/scp>\n                    alopecia areata in children: Onset earlier than 4\u2009years of age might have a better short\u2010term prognosis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4259-0366","authenticated-orcid":false,"given":"Ji\u2010Hoon","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyung Hee University hospital at Gangdong, Kyung Hee University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7295-5725","authenticated-orcid":false,"given":"Soon\u2010Hyo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyung Hee University hospital at Gangdong, Kyung Hee University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5300-6869","authenticated-orcid":false,"given":"Woo\u2010Young","family":"Sim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyung Hee University hospital at Gangdong, Kyung Hee University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4443-4161","authenticated-orcid":false,"given":"Bark\u2010Lynn","family":"Lew","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyung Hee University hospital at Gangdong, Kyung Hee University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.10.032"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5245(91)90078-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.08.045"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1989.tb02604.x"},{"key":"e_1_2_11_6_1","first-page":"494","article-title":"The impact of childhood atopic dermatitis on their families","volume":"38","author":"Shin N","year":"2000","journal-title":"Korean J Dermatol"},{"key":"e_1_2_11_7_1","first-page":"1778","volume-title":"Nelson Textbook of Pediatrics","author":"Kliegman RM","year":"2011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(99)70195-7"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14775"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16727"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.7.799"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000477458"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2002.00215.x"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.14991","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:13:02Z","timestamp":1761109982000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.14991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,21]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/exd.14991"],"URL":"https:\/\/doi.org\/10.1111\/exd.14991","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,21]]},"assertion":[{"value":"2023-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e14991"}}