{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:28:48Z","timestamp":1789921728247,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173419"],"award-info":[{"award-number":["82173419"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Psoriasis is a complex inflammatory skin disease with uncertain pathogenesis. eIF4E (eukaryotic translation initiation factor 4E) and its phosphorylation state p\u2010eIF4E are highly expressed in psoriatic tissues. However, the role eIF4E played in psoriasis is still unclear. To investigate the function of eIF4E and p\u2010eIF4E in psoriasis and to figure out whether eFT\u2010508 (Tomivosertib, eIF4E phosphorylation inhibitor) can relieve the disease severity and become a promising candidate for the psoriasis treatment. We first verified the expression of eIF4E and p\u2010eIF4E in psoriasis patients' lesional skin. Then, we demonstrated the effect of eIF4E and p\u2010eIF4E on the abnormal proliferation and inflammatory state of keratinocytes by using eIF4E\u2010specific small interfering RNA (si\u2010eIF4E) and eFT\u2010508. In this study, all cell experiments were performed under the psoriasis\u2010model condition. Moreover, the external application of eFT\u2010508 on imiquimod (IMQ)\u2010induced psoriasis mice was performed to explore its potential clinical value. Results showed that eIF4E and p\u2010eIF4E were significantly overexpressed in skin lesions of psoriasis patients. Knocking down eIF4E or adding eFT\u2010508 can relieve the abnormal proliferation and the excessive inflammatory state of keratinocytes by reducing the expression of cyclin D1, IL\u20101\u03b2, CXCL10, IL23, Wnt 5a, NBS1 and p\u2010AKT from mRNA or protein levels. Furthermore, these results were consistent with those obtained from the in\u00a0vitro experiments. Then, we conclude that eIF4E plays the role of the pathogenic gene in psoriasis, and eFT\u2010508 may be a promising candidate for anti\u2010prosoriasis drugs.<\/jats:p>","DOI":"10.1111\/exd.14997","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:14:16Z","timestamp":1704672856000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["eIF4E plays the role of a pathogenic gene in psoriasis, and the inhibition of eIF4E phosphorylation ameliorates psoriasis\u2010like skin damage"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5263-7845","authenticated-orcid":false,"given":"Ruijie","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Qilu Hospital, Cheeloo College of Medicine Shandong University  Jinan Shandong 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