{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:57:56Z","timestamp":1789041476555,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T00:00:00Z","timestamp":1704326400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019157","name":"Fundaci\u00f3n para el Fomento de la Investigaci\u00f3n Sanitaria y Biom\u00e9dica de la Comunitat Valenciana","doi-asserted-by":"publisher","award":["UGP\u201020\u2010131"],"award-info":[{"award-number":["UGP\u201020\u2010131"]}],"id":[{"id":"10.13039\/501100019157","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Biological therapies are safer and more effective against psoriasis than conventional treatments. Even so, 30\u201350% of psoriatic patients show an inadequate response, which is associated with individual genetic heterogeneity. Pharmacogenetic studies have identified several single nucleotide polymorphisms (SNPs) as possible predictive and prognostic biomarkers for psoriasis treatment response. The objective of this study was to determine the link between several SNPs and the clinical response to biological therapies in patients with moderate\u2013severe psoriasis. A set of 21 SNPs related to psoriasis and\/or other immunological diseases were selected and analysed from salivary samples of patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200988). Treatment effectiveness and patient improvement was assessed clinically through Relative Psoriasis Area and Severity Index (PASI), also called \u2018PASI response\u2019, as well as absolute PASI. Associations between SNPs and PASI factors were assessed at 3 and 12\u2009months for every treatment category of IL\u201017, IL\u201023, IL\u201012&amp;23 and TNF\u2010\u03b1 inhibitors. Multivariate correlation analysis and Fisher's exact test were used to analyse the relationship between SNPs and therapy outcomes. Several SNPs located in the\n                    <jats:italic>TLR2<\/jats:italic>\n                    ,\n                    <jats:italic>TLR5<\/jats:italic>\n                    ,\n                    <jats:italic>TIRAP<\/jats:italic>\n                    ,\n                    <jats:italic>HLA\u2010C<\/jats:italic>\n                    ,\n                    <jats:italic>IL12B<\/jats:italic>\n                    ,\n                    <jats:italic>SLC12A8<\/jats:italic>\n                    ,\n                    <jats:italic>TNFAIP3<\/jats:italic>\n                    and\n                    <jats:italic>PGLYRP4<\/jats:italic>\n                    genes demonstrated association with increased short and long\u2010term therapy\u2010effectiveness rates. Most patients achieved values of PASI response \u226575 or absolute PASI&lt;1, regardless of the biological treatment administered. In conclusion, we demonstrate a relationship between different SNPs and both short\u2010 and especially long\u2010term effectiveness of biological treatment in terms of PASI. These polymorphisms may be used as predictive markers of treatment response in patients with moderate\u2010to\u2010severe psoriasis, providing personalized treatment.\n                  <\/jats:p>","DOI":"10.1111\/exd.15003","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T01:43:44Z","timestamp":1704419024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between several immune response\u2010related genes and the effectiveness of biological treatments in patients with moderate\u2010to\u2010severe psoriasis"],"prefix":"10.1111","volume":"33","author":[{"given":"Alba","family":"Loras","sequence":"first","affiliation":[{"name":"Department of Medicine Jaume I University of Castellon  Castello de la Plana Spain"},{"name":"Department of Surgery University of Valencia  Valencia 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