{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:32:20Z","timestamp":1790947940695,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association between psoriasis and cardiovascular disease (CVD) has long been discussed and continually refined. However, there is currently a lack of prospective studies on the cardiovascular risk attributed to psoriasis in the United States general population. Representative adult participants were selected from the National Health and Nutrition Examination Survey (NHANES). Risks of cardiovascular symptoms and diseases prevalence were evaluated between participants with and without psoriasis. The hazards for all\u2010cause mortality and CVD mortality were stratified by psoriasis status. Mediation analysis was then conducted to identify potential mediators between psoriasis and cardiac death. Overall, 19\u2009741 participants were included in the current study, 542 (2.7%) had psoriasis and 19\u2009199 (97.3%) did not have psoriasis. After adjusting for known CVD risk factors, odds for hypertension (OR\u2009=\u20091.37, 95% CI: 1.13\u20131.66,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001), hypercholesterolemia (OR\u2009=\u20091.37, 95% CI: 1.13\u20131.64,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and angina pectoris (OR\u2009=\u20091.74, 95% CI: 1.11\u20132.60,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.011) were higher in psoriasis patients. Compared with participants without psoriasis, moderate\/severe but not mild patients showed significantly higher CVD mortality (HR\u2009=\u20092.55, 95% CI: 1.27\u20135.15,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.009). This result was supported by subgroup analyses. Mediation analysis further suggested that the direct effect of moderate\/severe psoriasis on CVD mortality accounted for 81.4% (65.8%\u201397.1%). Besides, the indirect effect might derive from disturbance of serum albumin, urea nitrogen and uric acid. Moderate\u2010to\u2010severe psoriasis is an independent risk factor for cardiovascular disease, making it necessary to regularly conduct cardiovascular disease\u2010related examinations for patients with higher severity of psoriasis in clinical settings.\n                  <\/jats:p>","DOI":"10.1111\/exd.15010","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T00:25:41Z","timestamp":1705710341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Prospective evaluation of cardiovascular risk and mortality in patients with psoriasis: An American population\u2010based study"],"prefix":"10.1111","volume":"33","author":[{"given":"Junyan","family":"Kan","sequence":"first","affiliation":[{"name":"Department of Cardiology Nanjing First Hospital, Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9259-179X","authenticated-orcid":false,"given":"Qitao","family":"Chen","sequence":"additional","affiliation":[{"name":"Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuwei","family":"Tao","sequence":"additional","affiliation":[{"name":"Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nanjing First Hospital, Nanjing Medical University  Nanjing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gu","sequence":"additional","affiliation":[{"name":"Wuxi Medical Center, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital Nanjing Medical University  Wuxi 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