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It is widely known that biologics could affect the metabolic status and comorbidities in psoriasis patients, however, the effects of biologics on metabolism in psoriasis patients remain poorly understood. The aim of this study was to elucidate the characteristic changes of metabolic profiling in psoriasis vulgaris (PsV) patients before and after applying biologics. Plasma samples were collected from a retrospective cohort of 43 PsV patients. Non\u2010targeted metabolomics analyses were performed using liquid chromatography\u2010mass spectrometry (LC\u2013MS) to compare the metabolic profiles before and after applying adalimumab (ADA) or ixekizumab (IXE) for 4\u2009weeks. Additionally, correlation analyses were conducted to investigate the associations between metabolite expression levels and clinical characteristics. The biologics significantly affected the metabolic profiles of PsV patients especially in glycerophospholipids (GPs). First, phosphatidylcholine (PC), unsaturated lysophosphatidylcholine (LPC), unsaturated lysophosphatidic acid (LPA) and unsaturated lysophosphatidylethanolamine (LPE) were significantly up\u2010regulated, whereas phosphatidylethanolamine (PE), saturated LPC, saturated LPA and saturated LPE were predominantly down\u2010regulated after biologic treatment. What is more, the changes in PE and LPA were mainly observed after applying IXE instead of ADA. Second, we also found GPs including PC, unsaturated LPC, unsaturated LPA and unsaturated LPE were primarily negatively correlated with disease severity, whereas, PE, saturated LPC, saturated LPA and saturated LPE displayed inverse correlations. Biologics could affect GP metabolism and facilitate the transition of metabolic status from a pro\u2010inflammatory to an anti\u2010inflammatory phenotype in PsV patients.<\/jats:p>","DOI":"10.1111\/exd.15011","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T07:28:51Z","timestamp":1705476531000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The impacts of biologic treatment on metabolic profiling in psoriasis"],"prefix":"10.1111","volume":"33","author":[{"given":"Sichun","family":"Deng","sequence":"first","affiliation":[{"name":"The Department of Dermatology, Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology  Changsha Hunan China"},{"name":"Furong Laboratory  Changsha Hunan China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis, Human Engineering 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Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.15011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:14:00Z","timestamp":1761110040000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.15011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/exd.15011"],"URL":"https:\/\/doi.org\/10.1111\/exd.15011","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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