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In this study, we sought to investigate the influence of the <jats:italic>ADAR1<\/jats:italic> gene on DSH both in\u00a0vitro and in\u00a0vivo. Morpholino knockdown of <jats:italic>adar1<\/jats:italic> in zebrafish produced phenotypes characterized by polarity changes, and abnormal migration and distribution of melanocytes. Differential expression of C\u2010KIT and distinct patterns of apoptosis between hyperpigmented and hypopigmented areas in DSH patient were detected by means of immunohistochemical methods and TUNEL assays, respectively. This study revealed that <jats:italic>adar1<\/jats:italic> knockdown in a zebrafish model resulted in abnormal migration and changes in the cell polarity of melanocytes, and provided novel insight into the mechanism of DSH pathogenesis.<\/jats:p>","DOI":"10.1111\/exd.15031","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T11:24:34Z","timestamp":1708428274000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of the pathogenesis of <scp>ADAR1<\/scp> gene in dyschromatosis symmetrica hereditaria"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2033-8386","authenticated-orcid":false,"given":"Jia","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai 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