{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:30:16Z","timestamp":1758810616176,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FONDECYT Regular 1220704"],"award-info":[{"award-number":["FONDECYT Regular 1220704"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidermolysis bullosa (EB) is a heritable skin blistering disease caused by variants in genes coding for proteins that secure cell\u2013cell adhesion and attachment of the epidermis to the dermis. Interestingly, several proteins involved in inherited EB are also associated with autoimmune blistering diseases (AIBD). In this study, we present a long\u2010term follow\u2010up of 15 patients suffering from recessive dystrophic or junctional EB. From these patients, 62 sera were analysed for the presence of autoantibodies associated with AIBD. We show that patients suffering from recessive dystrophic EB (RDEB) are more susceptible to developing autoantibodies against skin proteins than patients suffering from junctional EB (70% vs. 20%, respectively). Interestingly, no correlation with age was observed. Most patients showed reactivity to Type XVII collagen\/linear IgA bullous dermatosis autoantigen (<jats:italic>n<\/jats:italic>\u2009=\u20095; 33%), followed by BP230 (<jats:italic>n<\/jats:italic>\u2009=\u20094; 27%), Type VII collagen (<jats:italic>n<\/jats:italic>\u2009=\u20094; 27%) and laminin\u2010332 (<jats:italic>n<\/jats:italic>\u2009=\u20091; 7%). The pathogenicity of these autoantibodies remains a subject for future experiments.<\/jats:p>","DOI":"10.1111\/exd.15035","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T05:25:46Z","timestamp":1708665946000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Patients suffering from dystrophic epidermolysis bullosa are prone to developing autoantibodies against skin proteins: A longitudinal confirmational study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7550-6386","authenticated-orcid":false,"given":"J.","family":"Bremer","sequence":"first","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. H.","family":"Pas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F. H.","family":"Diercks","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. M.","family":"van der Molen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Nijenhuis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. L.","family":"van Nijen\u2010Vos","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Morand\u00e9","sequence":"additional","affiliation":[{"name":"DEBRA Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Yubero","sequence":"additional","affiliation":[{"name":"DEBRA Chile  Santiago Chile"},{"name":"Pediatrics and Pediatric Infectious Diseases of Cl\u00ednica Alemana, Facultad de Medicina Alemana Universidad del Desarrollo  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Palisson","sequence":"additional","affiliation":[{"name":"DEBRA Chile  Santiago Chile"},{"name":"Servicio de Dermatolog\u00eda, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8987-1317","authenticated-orcid":false,"given":"I.","family":"Fuentes","sequence":"additional","affiliation":[{"name":"DEBRA Chile  Santiago Chile"},{"name":"Centro de Gen\u00e9tica y Gen\u00f3mica, Facultad de Medicina Cl\u00ednica Alemana Universidad del Desarrollo  Santiago Chile"},{"name":"Departamento de Biolog\u00eda Celular y Molecular, Facultad de Ciencias Biol\u00f3gicas Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. G.","family":"Pasmooij","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Center for Blistering Diseases University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18921"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00626-3"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21769"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.10.030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-132"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.945176"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70094-X"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18129"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14920"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2011.11.010"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam7928"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14481"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000246936"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.929286"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101625"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.15035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T04:31:53Z","timestamp":1709094713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.15035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/exd.15035"],"URL":"https:\/\/doi.org\/10.1111\/exd.15035","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"type":"print","value":"0906-6705"},{"type":"electronic","value":"1600-0625"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15035"}}