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However, genetic testing is not routinely available in clinical practice for the diagnosis of GPP. Previously, GPP patients with acrodermatitis continua of Hallopeau (ACH) were found to have a high percentage of carrying <jats:italic>IL36RN<\/jats:italic> mutation. In this study, we reported six patients with pustular psoriasis presenting as diffuse palmoplantar erythema with keratoderma among 60 patients who carried <jats:italic>IL36RN<\/jats:italic> mutation. ACH was present in five patients and five patients had acute flare of GPP. This unique presentation may serve as a predictor for <jats:italic>IL36RN<\/jats:italic> mutation in patients with pustular psoriasis, similar to ACH.<\/jats:p>","DOI":"10.1111\/exd.15056","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T06:48:24Z","timestamp":1710571704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acquired diffuse palmoplantar erythema with keratoderma in Chinese patients with pustular psoriasis: A predictor for <scp>IL36<\/scp> receptor antagonist <i>c.115+6T&gt;C<\/i> mutation?"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-9913","authenticated-orcid":false,"given":"Francis Li\u2010Tien","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Medical Education National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-9720","authenticated-orcid":false,"given":"Chang\u2010Yu","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1498-1474","authenticated-orcid":false,"given":"Tsen\u2010Fang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-022-00881-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4951"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011741"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.038"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550260132488"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/s0190-9622(03)01479-8"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.04.043"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14386"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-021-00654-z"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14949"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14783"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdvl.IJDVL_581_19"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S391463"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"430","article-title":"An acrodermatitis continua of hallopeau evolving into generalized pustular psoriasis: a case series","volume":"32","author":"Damayanti N","year":"2022","journal-title":"J Pak Assoc Dermatol"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14794"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.038"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000528753"},{"key":"e_1_2_10_19_1","unstructured":"BurdenAD OkuboY ZhengM et\u00a0al.Effect of the presence or absence of genetic mutations on spesolimab efficacy in patients with generalized pustular psoriasis (GPP). 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