{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T17:42:19Z","timestamp":1790444539543,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010invasive diagnostics like line\u2010field confocal optical coherence tomography (LC\u2010OCT) are being implemented in dermato\u2010oncology. However, unification of terminology in LC\u2010OCT is lacking. By reviewing the LC\u2010OCT literature in the field of dermato\u2010oncology, this study aimed to develop a unified terminological glossary integrated with traditional histopathology. A PRISMA\u2010guided literature\u2010search was conducted for English\u2010language publications on LC\u2010OCT of actinic keratosis (AK), keratinocyte carcinoma (KC), and malignant melanoma (MM). Study characteristics and terminology were compiled. To harmonize LC\u2010OCT terminology and integrate with histopathology, synonymous terms for image features of AK, KC, and MM were merged by two authors, organized by skin layer and lesion\u2010type. A subset of key LC\u2010OCT image\u2010markers with histopathological correlates that in combination were typical of AK, squamous cell carcinoma in\u00a0situ (SCCis), invasive squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and MM in traditional histopathology, were selected from the glossary by an experienced dermatopathologist. Seventeen observational studies of AK (7 studies), KC (13 studies), MM (7 studies) utilizing LC\u2010OCT were included, with 117 terms describing either AK, KC, or MM. These were merged to produce 45 merged\u2010terms (61.5% reduction); 5 assigned to the stratum corneum (SC), 23 to the viable epidermis, 2 to dermo\u2010epidermal junction (DEJ) and 15 to the dermis. For each lesion, mandatory key image\u2010markers were a well\u2010defined DEJ and presence of mild\/moderate but not severe epidermal dysplasia for AK, severe epidermal dysplasia and well\u2010defined DEJ for SCCis, interrupted DEJ and\/or dermal broad infiltrative strands for invasive SCC, dermal lobules connected and\/or unconnected to the epidermis for BCC, as well as single atypical melanocytes and\/or nest of atypical melanocytes in the epidermis or dermis for MM. This review compiles evidence on LC\u2010OCT in dermato\u2010oncology, providing a harmonized histopathology\u2010integrated terminology and key image\u2010markers for each lesion. Further evaluation is required to determine the clinical value of these findings.<\/jats:p>","DOI":"10.1111\/exd.15057","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T10:59:41Z","timestamp":1713265181000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Line\u2010field confocal optical coherence tomography in dermato\u2010oncology: A literature review towards harmonized histopathology\u2010integrated terminology"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8577-6638","authenticated-orcid":false,"given":"Kevin","family":"Jacobsen","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-6717","authenticated-orcid":false,"given":"Vinzent Kevin","family":"Ortner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-5042","authenticated-orcid":false,"given":"Emily","family":"Wenande","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Sahu","sequence":"additional","affiliation":[{"name":"Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Paasch","sequence":"additional","affiliation":[{"name":"University of Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1250-2035","authenticated-orcid":false,"given":"Merete","family":"Haedersdal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg and Frederiksberg  Copenhagen Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.07.039"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.1187"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11360"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10830.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp255"},{"key":"e_1_2_12_7_1","unstructured":"Melanoma skin cancer statistics.Cancer Research UK. 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