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In theory, cells undergoing mesenchymal transition will achieve re\u2010epithelialization through mesenchymal\u2010epithelial transition at the end of wound healing. But in fact, some pathological stimuli will inhibit this biological process and result in scar formation. If mesenchymal\u2010epithelial transition can be activated at the corresponding stage, the ideal wound healing may be accomplished. Two in\u00a0vivo skin defect mouse models and dermal\u2010derived mesenchymal cells were used to evaluate the effect of lithium chloride in wound healing. The mesenchymal\u2010epithelial transition was detected by immunohistochemistry staining. In\u00a0vivo, differentially expressed genes were analysed by transcriptome analyses and the subsequent testing was carried out. We found that lithium chloride could promote murine cutaneous wound healing and facilitate mesenchymal\u2010epithelial transition in\u00a0vivo and in\u00a0vitro. In lithium chloride group, scar area was smaller and the collagen fibres are also orderly arranged. The genes related to mesenchyme were downregulated and epithelial mark genes were activated after intervention. Moreover, transcriptome analyses suggested that this effect might be related to the inhibition of CXCL9 and IGF2, subsequent assays demonstrated it. Lithium chloride can promote mesenchymal\u2010epithelial transition via downregulating CXCL9 and IGF2 in murine cutaneous wound healing, the expression of IGF2 is regulated by \u03b2\u2010catenin. It may be a potential promising therapeutic drug for alleviating postoperative scar and promoting re\u2010epithelialization in future.<\/jats:p>","DOI":"10.1111\/exd.15078","type":"journal-article","created":{"date-parts":[[2024,4,13]],"date-time":"2024-04-13T04:14:30Z","timestamp":1712981670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Lithium chloride promotes mesenchymal\u2010epithelial transition in murine cutaneous wound healing via inhibiting <scp>CXCL9<\/scp> and <scp>IGF2<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"given":"Chong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral Diseases &amp; National Center for Stomatology &amp; National Clinical Research Center for Oral Diseases &amp; Department of Cleft Lip and Palate Surgery, West China Hospital of Stomatology Sichuan University  Chengdu Sichuan 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