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The current aim was to find possible similarities and differences in protein expression patterns between these two major chronic inflammatory skin diseases. High\u2010throughput tandem mass spectrometry proteomic analysis was performed using full thickness skin samples from adult PS patients, AD patients and healthy subjects. We detected a combined total of 3045 proteins in the three study groups. According to principal component analysis, there was significant overlap between the proteomic profiles of PS and AD, and both clearly differed from that of healthy skin. The following validation of selected proteins with western blot analysis showed similar tendencies in expression levels and produced statistically significant results. The expression of periostin (POSTN) was consistently high in AD and very low or undetectable in PS (5% FDR corrected <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), suggesting POSTN as a potential biomarker to distinguish these diseases. Immunohistochemistry further confirmed higher POSTN expression in AD compared to PS skin. Overall, our findings support the concept that these two chronic skin diseases might share considerably more common mechanisms in pathogenesis than has been suspected thus far.<\/jats:p>","DOI":"10.1111\/exd.15079","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T05:24:28Z","timestamp":1713936268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["High\u2010throughput proteomic analysis of chronic inflammatory skin diseases: Psoriasis and atopic dermatitis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2749-8534","authenticated-orcid":false,"given":"Tanel","family":"Traks","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Institute of Clinical Medicine University of Tartu  Tartu Estonia"},{"name":"Clinical Research Centre, Tartu University Hospital University of Tartu  Tartu 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