{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:36:57Z","timestamp":1790800617909,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Erosive oral lichen planus (OLP) is a challenging disease. This T cell driven disorder frequently shows a treatment unresponsive course and strongly limits patients' quality of life. The disease lacks FDA or EMA approved drugs for its treatment and the efficacy of the commonly administered treatments (i.e. topical and systemic steroids, steroid sparing agents) is often only partial. Although the etiopathogenesis of the disease still needs to be fully elucidated, recent advances helped to identify interferon\u2010\u0263 (IFN\u2010\u0263) as a pivotal cytokine in OLP pathogenesis, thus making the interference with its signalling a therapeutic target. Janus kinase (JAK) inhibitors therefore gained relevance for their inhibitory effect on IFN\u2010\u0263 signalling. While some drugs such as abrocitinib, upadacitinib, tofacitinib directly interfere with IFN\u2010\u0263 signalling through blockade of JAK1 and\/or JAK2, deucravacitinib, a selective TYK\u20102 inhibitor indirectly interferes on IFN\u2010\u0263 activation through interference with interleukin (IL)\u201012, a potent promotor for Th1\/IFN\u2010\u0263 responses. This mechanism of action makes deucravacitinib a candidate drug for the treatment of OLP. Here we provide initial evidence that deucravacitinib 6\u2009mg daily has a beneficial effect in three patients with oral OLP.<\/jats:p>","DOI":"10.1111\/exd.15080","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T06:20:01Z","timestamp":1713334801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["<scp>TYK2<\/scp> inhibition with deucravacitinib ameliorates erosive oral lichen planus"],"prefix":"10.1111","volume":"33","author":[{"given":"Kim Natalie","family":"Stolte","sequence":"first","affiliation":[{"name":"Department of Periodontology, Oral Medicine and Oral Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"Berlin Institute of Health at Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin BIH Biomedical Innovation Academy, BIH Charit\u00e9 Clinician 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Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Oral Medicine and Oral Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5526-7517","authenticated-orcid":false,"given":"Kamran","family":"Ghoreschi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin, Humboldt\u2010Universit\u00e4t zu Berlin  Berlin 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