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Expression defects are associated with pigmentary and mast cell disorders. KIT ligand regulation is complex but efficient targeting of this system would be of significant benefit to those suffering from melanocytic or mast cell disorders. Herein, we review the known associations of this pathway with cutaneous diseases and the regulators of this system both in skin and in the more well\u2010studied germ cell system. Exogenous agents modulating this pathway will also be presented. Ultimately, we will review potential therapeutic opportunities to help our patients with melanocytic and mast cell disease processes potentially including vitiligo, hair greying, melasma, urticaria, mastocytosis and melanoma.<\/jats:p>","DOI":"10.1111\/exd.15091","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T04:38:35Z","timestamp":1715056715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic modulation of <scp>KIT<\/scp> ligand in melanocytic disorders with implications for mast cell diseases"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7111-8557","authenticated-orcid":false,"given":"Alec","family":"Sevilla","sequence":"first","affiliation":[{"name":"Department of Dermatology New York Medical College  New York New York USA"},{"name":"Department of Internal Medicine Lakeland Regional Health  Lakeland Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Grichnik","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Cutaneous Surgery Morsani College of Medicine, University of South Florida  Tampa Florida USA"},{"name":"Department of Cutaneous Oncology Moffitt Cancer Center  Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90176-H"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00272.x"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12478.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700164"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.67"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-206045"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.011"},{"issue":"4","key":"e_1_2_13_9_1","first-page":"965","article-title":"The c\u2010kit receptor, stem cell factor, and mast cells. 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