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This in\u00a0vitro study assessed the effects of three wound\u2010dressings (a pure Ca<jats:sup>2+<\/jats:sup> alginate: Algost\u00e9ril\u00ae, a Ca<jats:sup>2+<\/jats:sup> alginate + carboxymethylcellulose: Biatain alginate\u00ae and a polyacrylate impregnated with lipido\u2010colloid matrix: UrgoClean\u00ae) on dermal fibroblast activity. The results showed the pure calcium alginate to be non\u2010cytotoxic, whereas the other wound\u2010dressings showed moderate to strong cytotoxicity. The two alginates stimulated fibroblast migration and proliferation, whereas the polyacrylate altered migration and had no effect on proliferation. The pure Ca<jats:sup>2+<\/jats:sup> alginate significantly increased the TGF\u2010\u03b2\u2010induced fibroblast activation, which is essential to healing. This activation was confirmed by a significant increase in Vascular endothelial growth factor (VEGF) secretion and a higher collagen production. The other dressings reduced these fibroblast activities. The pure Ca<jats:sup>2+<\/jats:sup> alginate was also able to counteract the inhibitory effect of NK cell supernatants on fibroblast migration. These in\u00a0vitro results demonstrate that tested wound\u2010dressings are not equivalent for fibroblast activation. Only Algost\u00e9ril was found to promote all the fibroblast activities tested, which could contribute to its healing efficacy demonstrated in the clinic.<\/jats:p>","DOI":"10.1111\/exd.15098","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T07:45:03Z","timestamp":1716277503000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["In vitro effects of wound\u2010dressings on key wound healing properties of dermal fibroblasts"],"prefix":"10.1111","volume":"33","author":[{"given":"S.","family":"Peltier","sequence":"first","affiliation":[{"name":"Inserm UMRS_976, H\u00f4pital Saint\u2010Louis  Paris France"},{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6154-7662","authenticated-orcid":false,"given":"Y.","family":"Adib","sequence":"additional","affiliation":[{"name":"Inserm 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