{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:24:00Z","timestamp":1791015840466,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T00:00:00Z","timestamp":1717977600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Itchy skin or pruritus is a common cutaneous symptom that causes an urge to scratch, and the role of interleukins (IL) in itchy skin has been widely studied. IL\u20104 and IL\u201013 are known to induce chronic itch. Similarly, the direct role of IL\u201031 in inducing itch has been demonstrated in clinical situations such as atopic dermatitis and prurigo nodularis. Moreover, IL\u20104 receptor \u03b1 antibodies (dupilumab) and IL\u201031 receptor A antibodies (nemolizumab) inhibit pruritus. However, the interplay between these ILs in pruritus remains unclear. Therefore, we investigated the reciprocal effects of these cytokines on pruritus in mice. The intradermal administration of IL\u201031 induced itch\u2010associated scratching behaviour in a dose\u2010dependent manner. Interestingly, the amount of IL\u201031 and IL\u20104\/IL\u201013, co\u2010administration or 30\u2009min pre\u2010administration of IL\u20104\/IL\u201013 and intradermal or intravenous pre\u2010administration of IL\u20104 did not affect IL\u201031\u2010induced itch\u2010associated scratching behaviour when it was observed for 30\u2009min, 2\u2009h, 24\u2009h or 48\u2009h. Pre\u2010administration of neutralising antibodies against IL\u20104 and IL\u201013 also did not affect IL\u201031\u2010induced itch\u2010associated scratching behaviour. These results suggest that IL\u201031 can induce itching independently of IL\u20104 and IL\u201013 in\u00a0vivo.<\/jats:p>","DOI":"10.1111\/exd.15115","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T10:29:03Z","timestamp":1718015343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>IL<\/scp>\u20104 and <scp>IL<\/scp>\u201013 are not involved in <scp>IL<\/scp>\u201031\u2010induced itch\u2010associated scratching behaviour in mice"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-3950","authenticated-orcid":false,"given":"Rana","family":"Kawai","sequence":"first","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8649-9073","authenticated-orcid":false,"given":"Nao","family":"Ichimasu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-6994","authenticated-orcid":false,"given":"Kazumoto","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314768"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31191-1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicines6030072"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14422"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12222"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.045"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14279"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.11.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908316"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.10.033"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02320-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2016.12.015"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701138"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.022"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18356"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.15115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T15:22:27Z","timestamp":1722525747000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.15115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/exd.15115"],"URL":"https:\/\/doi.org\/10.1111\/exd.15115","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-09-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e15115"}}