{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:54:05Z","timestamp":1788778445776,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The management of hypertrophic scars (HSs), characterized by excessive collagen production, involves various nonsurgical and surgical interventions. However, the absence of a well\u2010defined molecular mechanism governing hypertrophic scarring has led to less\u2010than\u2010ideal results in clinical antifibrotic treatments. Therefore, our study focused on the role of decorin (DCN) and its regulatory role in the TGF\u2010\u03b2\/Smad signalling pathway in the development of HSs. In our research, we observed a decrease in DCN expression within hypertrophic scar tissue and its derived cells (HSFc) compared to that in normal tissue. Then, the inhibitory effect of DCN on collagen synthesis was confirmed in Fc and HSFc via the detection of fibrosis markers such as COL\u20101 and COL\u20103 after the overexpression and knockdown of DCN. Moreover, functional assessments revealed that DCN suppresses the proliferation, migration and invasion of HSFc. We discovered that DCN significantly inhibits the TGF\u2010\u03b21\/Smad3 pathway by suppressing TGF\u2010\u03b21 expression, as well as the formation and phosphorylation of Smad3. This finding suggested that DCN regulates the synthesis of collagen\u2010based extracellular matrix and fibrosis through the TGF\u2010\u03b21\/Smad3 pathway.<\/jats:p>","DOI":"10.1111\/exd.15133","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T07:10:29Z","timestamp":1721805029000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Decorin attenuates hypertrophic scar fibrosis via\n                    <scp>TGF\u03b2<\/scp>\n                    \/Smad signalling"],"prefix":"10.1111","volume":"33","author":[{"given":"Jiangtao","family":"Cui","sequence":"first","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Laboratory Center of Stomatology, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Department of Cranio\u2010Maxillofacial Trauma and Plastic Surgery, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Biomedical Experimental Center of Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Laboratory Center of Stomatology, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Department of Cranio\u2010Maxillofacial Trauma and Plastic Surgery, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Acharya","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Laboratory Center of Stomatology, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Department of Cranio\u2010Maxillofacial Trauma and Plastic Surgery, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Laboratory Center of Stomatology, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi China"},{"name":"Department of Cranio\u2010Maxillofacial Trauma and Plastic Surgery, College of Stomatology Xi'an Jiaotong University  Xi'an Shaanxi 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