{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:46:30Z","timestamp":1780083990159,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T00:00:00Z","timestamp":1722297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Detecting the association of genetic variants to the response of biological therapy represents an important advance in developing a personalized therapy. The aim of this work was to study the association of polymorphisms with an optimal response to tildrakizumab in patients with psoriasis in a real\u2010life clinical practice. Ninety patients with plaque psoriasis recruited from\u2014Spanish hospitals receiving tildrakizumab for at least 24\u2009weeks were genotyped for 180 polymorphisms. Optimal response to tildrakizumab was evaluated by absolute PASI \u22641 at 6 and 12\u2009months. Polymorphisms corrected for weight and disease duration with an FDR &lt;0.15 were included in a multiple regression model. Sixty three percent of patients achieved an absolute PASI \u22641 at 6\u2009months, while 71% did so after 12\u2009months. Disease duration (&gt;27\u2009years) and weight (&gt;76\u2009kg) were associated with treatment response; after correcting by these factors, no association (FDR &gt;0.15) was found for any polymorphism and response to tildrakizumab at 6\u2009months. The analysis at 12\u2009months identified the genotype GG for rs610604 (<jats:italic>TNFAIP3<\/jats:italic>), CT for rs9373839 (<jats:italic>ATG5<\/jats:italic>), and delCTGT\/delCTGT for rs72167053 (<jats:italic>PDE4D<\/jats:italic>) as risk factors to not achieve an optimal response (PASI \u22641), while CT for rs708567 (<jats:italic>IL17RC<\/jats:italic>) was protective, independently of weight and disease duration (FDR &lt;0.15). The final multivariable model at 12\u2009months showed an AUC of 0.90 (95% CI 0.82 to \u22120.98). We identified a set of polymorphisms that could be helpful to identify psoriatic patients with an optimal response to tildrakizumab at 12\u2009months in real\u2010world practice conditions.<\/jats:p>","DOI":"10.1111\/exd.15152","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T06:26:30Z","timestamp":1722407190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic polymorphisms to identify patients with an optimal response to tildrakizumab in psoriasis patients from real\u2010life clinical practice"],"prefix":"10.1111","volume":"33","author":[{"given":"B.","family":"Butr\u00f3n\u2010Bris","sequence":"first","affiliation":[{"name":"Servicio de Dermatolog\u00eda Instituto de Investigaci\u00f3n Sanitaria La Princesa, Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Llamas\u2010Velasco","sequence":"additional","affiliation":[{"name":"Servicio de Dermatolog\u00eda Instituto de Investigaci\u00f3n Sanitaria La Princesa, Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"Ovejero\u2010Benito","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas y de la Salud, Facultad de Farmacia Universidad San Pablo\u2010CEU, CEU, CEU Universities Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Santos\u2010Juanes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Central de Asturias  Asturias Spain"},{"name":"Grupo de Investigaci\u00f3n en Dermatolog\u00eda (GRIDER) Universidad de Oviedo  Oviedo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mart\u00ednez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de las Nieves  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ruiz\u2010Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology 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