{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T18:19:48Z","timestamp":1787422788192,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a double\u2010blind, randomized controlled trial, we investigated the effectiveness of adding antiplatelet drugs to up\u2010dosing antihistamines for the treatment of chronic spontaneous urticaria (CSU) in patients with elevated D\u2010dimer levels who had an inadequate response to conventional antihistamine doses. Twenty patients with Urticaria Activity Score over 7\u2009days (UAS7) \u226516 and D\u2010dimer &gt;500\u2009ng\/mL were randomized to receive either antiplatelet therapy (cilostazol 150\u2009mg\/day + dipyridamole 50\u2009mg\/day) with antihistamine (desloratadine 20\u2009mg\/day) or antihistamine alone for 4\u2009weeks. The antiplatelet group demonstrated a greater decrease in UAS7 compared to the control group (28.10 to 8.90 vs. 22.90 to 16.40, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 vs. <jats:italic>p<\/jats:italic>\u2009=\u20090.054). Both groups experienced improved quality of life (DLQI), but the improvement was greater in the antiplatelet group (<jats:italic>p<\/jats:italic>\u2009=\u20090.046). D\u2010dimer levels decreased only in the antiplatelet group (1133.67\u2009ng\/mL to 581.89\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.013) with no significant change observed in the control group. This suggests that combining dipyridamole and cilostazol with up\u2010dosing antihistamines may be more effective for CSU patients with high D\u2010dimer levels compared to up\u2010dosing antihistamines alone. This could be due to a reduction in platelet activation, as evidenced by the decrease in D\u2010dimer levels observed in the antiplatelet group.<\/jats:p>","DOI":"10.1111\/exd.15168","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:56:37Z","timestamp":1724396197000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combining dipyridamole and cilostazol with up\u2010dosing antihistamines improves outcomes in chronic spontaneous urticaria with high D\u2010dimer levels: A randomized controlled trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Amornrat","family":"Prasertcharoensuk","sequence":"first","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-4123","authenticated-orcid":false,"given":"Yuda","family":"Chongpison","sequence":"additional","affiliation":[{"name":"Research Affairs, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pattarawat","family":"Thantiworasit","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9971-4318","authenticated-orcid":false,"given":"Supranee","family":"Buranapraditkun","sequence":"additional","affiliation":[{"name":"Division of Allergy and Clinical Immunology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok 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