{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:56:06Z","timestamp":1789145766855,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we aimed to examine the relationship between the serum cytokine levels of patients with pemphigus vulgaris (PV) and the Pemphigus Disease Area Index (PDAI), along with the presence of anti\u2010desmoglein (Dsg) 1 antibody, anti\u2010Dsg3 antibody and co\u2010infection among patients with pemphigus vulgaris. This retrospective study included 62 PV patients and 59 healthy individuals who attended the Second Affiliated Hospital of Kunming Medical University from November 2014 to November 2022. The serum concentrations of cytokines and chemokines were assessed using the Luminex 200 System (a high\u2010throughput cytokine detection method). Additionally, anti\u2010Dsg1 and anti\u2010Dsg3 antibodies were determined through enzyme\u2010linked immunosorbent assay, while disease severity was evaluated using the PDAI scoring system. The PV group exhibited elevated levels of Th1 cytokines (such as interleukin (IL)\u20101RA, IL\u20101\u03b2, IL\u20102, IL\u201012p70, GM\u2010CSF, TNF\u2010\u03b1, IL\u201018, IFN\u2010\u03b3), Th2 cytokines (IL\u20105, IL\u201010, IL\u201013) and Th17\/Th22\u2010related cytokines (IL\u201017A, IL\u201022) compared to the healthy control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Conversely, the levels of chemokines (macrophage inflammatory protein\u20101 alpha (MIP\u20101\u03b1), stromal cell\u2010derived factor\u20101 alpha (SDF\u20101\u03b1), interferon\u2010inducible protein\u201010 (IP\u201010), Regulated on Activation in Normal T\u2010Cell Expressed And Secreted (RANTES), growth\u2010regulated on\u2010gene\u2010alpha (GRO\u2010\u03b1), MIP\u20101\u03b2) and Th2 (IL\u201031) were lower in the PV group compared to the healthy control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). No significant differences were observed in other cytokines and chemokines (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Additionally, IL\u20107, IFN\u2010\u03b3, IL\u201018 and GRO\u2010\u03b1 showed positive correlations with PDAI, IL\u20106 correlated positively with anti\u2010Dsg3 antibody levels, and IL\u201012p70, IL\u201018, and IFN\u2010\u03b3 correlated positively with anti\u2010Dsg1 antibody levels. Furthermore, IL\u201015 exhibited a positive association with skin infections. PV patients have elevated levels of various cytokines and chemokines, and there are different degrees of elevation in cytokines and chemokines associated with the activation of various T cell subsets. PDAI and the Dsg1 antibody levels are mainly related to the Th1\u2010related cytokines.<\/jats:p>","DOI":"10.1111\/exd.15173","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T08:49:25Z","timestamp":1725871765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of serum cytokines and chemokines levels and clinical significance in patients with pemphigus vulgaris\u2014A retrospective study"],"prefix":"10.1111","volume":"33","author":[{"given":"Shuqiong","family":"You","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Kunming Medical University  Kunming Yunnan 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