{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:55:12Z","timestamp":1781736912551,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,15]],"date-time":"2024-09-15T00:00:00Z","timestamp":1726358400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007514","name":"Universit\u00e0 di Pisa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007514","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a chronic skin disease, characterized by clinical inflammation of the hair follicle with the recurrence of abscesses, nodules, and tunnels. Recently, several studies suggested a role of IL\u20101 family (IL\u20101F) cytokines in eliciting and sustaining the disease. The aim of this work is to perform a comprehensive analysis of IL\u20101F cytokines, soluble inhibitors and receptors in a cohort of HS patients not treated with biological agents. Sixteen patients affected by HS and 16 healthy controls were recruited; clinical data were collected and disease severity evaluated by means of the International HS Severity Score System (IHS4). Serum levels of IL\u20101F cytokines, inhibitors and receptors were measured using a Multiplex Assays. IL\u201018 and free IL\u201018 levels were significantly higher in patients vs controls. Among soluble inhibitors, IL\u20101Ra, IL\u20101R2 and ST2\/IL\u20101R4 were significantly increased. IL\u201018, free IL\u201018 and IL\u201033 levels are strongly correlated with IHS4. Also the inhibitors IL\u20101Ra and IL\u201018BP show a correlation with IHS4. The data obtained in this study confirm the involvement of IL\u20101F cytokines in mediating the disease and determining its severity and suggest a possible role for IL\u201018 as novel serum biomarker of active disease.<\/jats:p>","DOI":"10.1111\/exd.15179","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:49:36Z","timestamp":1726451376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interleukin\u20101 family cytokines and soluble receptors in hidradenitis suppurativa"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9593-9357","authenticated-orcid":false,"given":"Flavia","family":"Manzo Margiotta","sequence":"first","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology Unit Pisa University Hospital  Pisa Italy"},{"name":"Health Science Interdisciplinary Center, Sant'Anna School of Advanced Studies  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-0244","authenticated-orcid":false,"given":"Gaetana","family":"Gambino","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7226-0907","authenticated-orcid":false,"given":"Federico","family":"Pratesi","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Michelucci","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology Unit Pisa University Hospital  Pisa Italy"},{"name":"Health Science Interdisciplinary Center, Sant'Anna School of Advanced Studies  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pisani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Clinical Immunology and Allergy Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-8695","authenticated-orcid":false,"given":"Leonardo","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4639-3167","authenticated-orcid":false,"given":"Valentina","family":"Dini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4127-0141","authenticated-orcid":false,"given":"Marco","family":"Romanelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology Unit Pisa University Hospital  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6433-4964","authenticated-orcid":false,"given":"Paola","family":"Migliorini","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Clinical Immunology and Allergy Unit Pisa University Hospital  Pisa 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