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This study aimed to investigate the biodistribution of iron oxide pigment to internal organs in mice. Moreover, when exposed to a static magnetic field, we studied whether any reactions followed in the tattooed skin. Twenty\u2010seven hairless C3.Cg\u2010Hrhr\/TifBomTac mice were included; 20 were tattooed with iron oxide ink in a rectangular 3\u2009cm<jats:sup>2<\/jats:sup> pattern; seven were controls. Ten of the tattooed mice were exposed to a 3\u2009T MRI scanner's static magnetic field. Following euthanasia, evaluations of dissected organs involved MRI T2*\u2010mapping, light microscopy (LM) and metal analysis. T2*\u2010mapping measures the relaxation times of hydrogen nuclei in water and fat, which may be affected by neighbouring ferrimagnetic particles, thus enabling the detection of iron oxide particles in organs. Elemental analysis detected a significant level of metals in the tattooed skin compared to controls, but no skin reactions occurred when exposed to a 3\u2009T static magnetic field. No disparity was observed in the liver samples with metal analysis. T2* mapping found no significant difference between the two groups. Only minute clusters of pigment particles were observed in the liver by LM. Our results demonstrate a minimal systemic distribution of the iron oxide pigments to the liver, whereas the kidney and brain were unaffected. The static magnetic field did not trigger skin reactions in magnetic tattoos but may induce image artefacts during MRI.<\/jats:p>","DOI":"10.1111\/exd.15183","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T01:20:33Z","timestamp":1726881633000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biodistribution of iron oxide tattoo pigment: An experimental murine study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1706-6383","authenticated-orcid":false,"given":"Kasper K\u00f8hler","family":"Alsing","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg  Copenhagen Denmark"},{"name":"Copenhagen Wound Healing Centre Copenhagen University Hospital \u2013 Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Hjorth","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus Hvass","family":"Hansen","sequence":"additional","affiliation":[{"name":"Section for Radiation Therapy, Department of Oncology, Center for Cancer and Organ Diseases Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina L\u00f8th","family":"M\u00e5rtensson","sequence":"additional","affiliation":[{"name":"Department of Pathology Copenhagen University Hospital \u2013 Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Pergament","family":"Persson","sequence":"additional","affiliation":[{"name":"Department of Plant and Environmental Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Qvortrup","sequence":"additional","affiliation":[{"name":"Core Facility for Integrated Microscopy, Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Christian","family":"Wulf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-6424","authenticated-orcid":false,"given":"Catharina Margrethe","family":"Lerche","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital \u2013 Bispebjerg  Copenhagen Denmark"},{"name":"Department of Pharmacy University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369175"},{"key":"e_1_2_11_3_1","unstructured":"SchaefferK DineshS.How many Americans have tattoos why and do they regret it? 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