{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:26:04Z","timestamp":1789961164783,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Psoriasis is a chronic autoimmune disease with a long disease course and frequent relapse characteristics. It is now recognised to be associated with epidermal environments of inflammatory cytokines. However, its pathogenesis is still not completely clear. We found the haemorheology of psoriatic patients to be abnormal, and ageing and deformed erythrocytes increased in the blood. The abnormal erythrocytes were more likely to induce psoriasis, which was confirmed in a mouse model induced by different blood components of psoriatic patients\/healthy volunteers. Spleen filtration dysfunction, which caused abnormal erythrocytes, was also more likely to induce psoriasis, which was confirmed in a mouse model induced by splenectomy. The mechanism was the weakening of the \u2018eat me\u2019 function of spleen macrophages phagocytizing ageing and deformed erythrocytes, resulting in the dysfunction of spleen filtration and the increase of ageing and deformed erythrocytes in the body. Additionally, the decreased oxygen\u2010carrying capacity and the declined antioxidant capacity of those erythrocytes led to the hypoxia environment, making psoriasis more likely to be induced. These findings demonstrate that spleen filtration dysfunction contributes to the pathogenesis of psoriasis and suggest that improving it may be an effective therapy for psoriasis and control its relapse.<\/jats:p>","DOI":"10.1111\/exd.70003","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:58:33Z","timestamp":1729580313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased Abnormal Erythrocytes Caused by Spleen Filtration Deficiency Provide a Hypoxic Environment for the Occurrence of Psoriasis"],"prefix":"10.1111","volume":"33","author":[{"given":"Ya","family":"Zhao","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayun","family":"Wu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dancai","family":"Fan","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigui","family":"Deng","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9554-3897","authenticated-orcid":false,"given":"Ruizhi","family":"Zhao","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanjian","family":"Lu","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m1590"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0377-2"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14864"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10677"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8702-3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2019.1555235"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19380"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2014.09.002"},{"key":"e_1_2_10_10_1","article-title":"E\u2010Selectin: A Biomarker of Cardiovascular Disease Risk With Potential Utility in Patients With Psoriasis","volume":"131","author":"Laws P.","year":"2011","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12895"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.14032"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.09.042"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05505"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-012-0260-8"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.08.004"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04393.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20940"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2008.06785.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2021.158943"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.05.007"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1999.01367.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2010-1307"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1606751113"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1669"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806501115"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001458"},{"key":"e_1_2_10_28_1","first-page":"24","article-title":"Dependence of Erythrocyte Deformability on the Human Age","volume":"17","author":"Goris A. P.","year":"2013","journal-title":"Lazernaya Meditsina"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-10-386805"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-141890"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171208"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/13102818.2018.1429310"},{"key":"e_1_2_10_33_1","first-page":"191","article-title":"Changes in Erythrocyte Aggregation and Deformability During Human Ageing","volume":"82","author":"Jayavanth S.","year":"2002","journal-title":"Current Science India"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00595411"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600867743"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2004.09.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803413944"},{"key":"e_1_2_10_38_1","first-page":"97","article-title":"Targeting Vegf\/Vegfr in the Treatment of Psoriasis","volume":"18","author":"Li W.","year":"2014","journal-title":"Discovery Medicine"},{"key":"e_1_2_10_39_1","first-page":"185","article-title":"Study on the Correlation Between Plasma Endothelin and Psychological Factors, as Well as the Severity of Psoriasis in Qinghai Region","volume":"45","author":"Zhou J. Y.","year":"2016","journal-title":"Journal of Clinical Dermatology"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175459"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_717_16"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27569"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S212781"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001464"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120142"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvu017"},{"key":"e_1_2_10_47_1","first-page":"544","article-title":"Study on the Rule of Distribution of Tcm Syndromes of Psoriasis","volume":"51","author":"Li T. H.","year":"2010","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.286"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4268681"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14584"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12627"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.649591"},{"key":"e_1_2_10_53_1","first-page":"4171","article-title":"Discussion on the Synergy Rule of PSORI\u2010CM02 in Treating Psoriasis Based on Pharmacodynamic\u2010Component Analysis","volume":"35","author":"Liu L. J.","year":"2020","journal-title":"China Journal of Traditional Chinese Medicine and Pharmacy"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:43:34Z","timestamp":1764636214000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.70003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/exd.70003"],"URL":"https:\/\/doi.org\/10.1111\/exd.70003","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70003"}}