{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:53:50Z","timestamp":1760014430542,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Dupilumab, an anti\u2010interleukin (IL)\u20104 receptor \u03b1\u2010antibody, was approved in 2018 for the treatment of moderate\u2010to\u2010severe atopic dermatitis (AD) in Japan. Although real\u2010world data have accumulated on the effectiveness and safety of dupilumab in patients with AD in the short term, real\u2010world data on its long\u2010term use are limited. In this study, we retrospectively investigated its effectiveness, safety and laboratory data in patients with AD who received dupilumab for 3\u2009years. All adult patients with moderate\u2010to\u2010severe AD who were administered dupilumab between June 2018 and December 2020 and were treated with dupilumab for more than 3\u2009years were included in this study. Sixty Japanese patients with AD (male, 48; female, 12) were included in this study. Their mean age was 36.6\u2009\u00b1\u200911.0 (standard deviation) years. The mean Eczema Area and Severity Index (EASI) was 29.9\u2009\u00b1\u20099.2. The clinical severity scales, including Investigator's Global Assessment (IGA), EASI and affected body surface area (BSA), and patient\u2010reported outcomes, such as Dermatology Quality Life Index (DLQI), Patient\u2010Oriented Eczema Measure (POEM) and visual analogue scale (VAS) of pruritus, significantly improved at 3\u2009months, and at 1, 2 and 3\u2009years after initiating dupilumab. The total EASI score significantly decreased by a mean of 66.8% at 3\u2009months, 81.0% at 1\u2009year, 85.3% at 2\u2009years and 90.0% at 3\u2009years after initiating dupilumab. The serum levels of thymus and activation\u2010regulated chemokine (TARC), immunoglobulin E (IgE) and lactate dehydrogenase (LDH) significantly decreased at 1, 2 and 3\u2009years. A slight decrease in circulating neutrophils was observed in patients with AD treated with dupilumab over periods from 3\u2009months to 3\u2009years. The number of circulating eosinophils significantly decreased at 2 and 3\u2009years after initiating dupilumab. The most common adverse event was ocular disorders observed in 23 patients (38.3%). Our study shows the sustained effectiveness and tolerable safety of 3\u2010year usage of dupilumab in Japanese patients with atopic dermatitis. Furthermore, dupilumab decreased neutrophil values at 3\u2009months and later, and reduced the number of circulating eosinophils after long\u2010term use (\u2267\u20092\u2009years).<\/jats:p>","DOI":"10.1111\/exd.70010","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T09:48:37Z","timestamp":1730540917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Experience of 3\u2010Year Treatment With Dupilumab: Significant Decrease in Circulating Neutrophils and Eosinophils in Japanese Patients With Atopic Dermatitis"],"prefix":"10.1111","volume":"33","author":[{"given":"Hideyuki","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine  Itabashi\u2010ku Tokyo 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