{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:51:15Z","timestamp":1791921075674,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002619","name":"Ajou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Senescent melanocytes have been suggested to play a role in the development of ageing\u2010associated pigmentary changes and skin ageing. Here, we assessed the senolytic capacity of recognised senolytic chemicals and natural compounds in UV\u2010irradiated senescent melanocytes. Among the tested agents, only ABT\u2010737 and ABT\u2010263 showed a significant reduction in the number of SA\u2010\u03b2\u2010Gal\u2010positive senescent melanocytes and in the expressions of p16\n                    <jats:sup>INK4A<\/jats:sup>\n                    and p21\n                    <jats:sup>Waf1<\/jats:sup>\n                    . The senolytic effects of the ABT drugs were associated with increased expression of cleaved caspase\u20103, which was hindered with a caspase inhibitor, Z\u2010VAD. These findings indicate that ABT\u2010737 and ABT\u2010263 eliminate senescent melanocytes through caspase\u2010mediated apoptosis, suggesting their future potential to address ageing skin.\n                  <\/jats:p>","DOI":"10.1111\/exd.70037","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T06:44:17Z","timestamp":1737614657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Senolytic Targeting of Anti\u2010Apoptotic Bcl Family Increases Cell Death in\n                    <scp>UV<\/scp>\n                    \u2010Irradiated Senescent Melanocytes: Search for Senolytics"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-8811","authenticated-orcid":false,"given":"Jin Cheol","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine; Suwon  Suwon Korea"},{"name":"Inflammaging Translational Research Center Ajou University Medical Center; Suwon  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine; Suwon  Suwon Korea"},{"name":"Department of Biomedical Sciences Graduate School of Ajou University  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeongeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine; Suwon  Suwon Korea"},{"name":"Inflammaging Translational Research Center Ajou University Medical Center; Suwon  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du Jin","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine; Suwon  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jun","family":"Park","sequence":"additional","affiliation":[{"name":"Inflammaging Translational Research Center Ajou University Medical Center; Suwon  Suwon Korea"},{"name":"Department of Biochemistry and Molecular Biology Ajou University Graduate School of Medicine; Suwon  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-4292","authenticated-orcid":false,"given":"Hee Young","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine; Suwon  Suwon Korea"},{"name":"Inflammaging Translational Research Center Ajou University Medical Center; Suwon  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1122446"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05092"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.01.027"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00837.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12234"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13814"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.09.031"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12994"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.365"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.26975"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.016"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.03.035"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.84912"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20893"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2004.01.017"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16350"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01923-y"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18051"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2021.05.003"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-019-00113-y"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.14969"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.03.161"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101982"},{"issue":"12","key":"e_1_2_9_26_1","first-page":"3111","article-title":"Current Understanding of the Role of Senescent Melanocytes in Skin Ageing","volume":"10","author":"Hughes B. 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