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Long non\u2010coding RNAs (lncRNAs) are non\u2010protein\u2010coding transcripts &gt;\u2009500 nucleotides with diverse regulatory functions; their role in epidermal dysfunction in psoriasis is poorly understood. To identify epidermal transcripts with potential roles in psoriasis, including lncRNAs, we performed RNA sequencing on keratinocytes from psoriasis and healthy skin. We identified 889 differentially expressed lncRNAs, many of which with yet unknown functions. RP11\u2010295G20.2 was identified as a lncRNA significantly induced in psoriasis keratinocytes, and this was verified by qRT\u2010PCR and by single\u2010molecule in\u00a0situ hybridisation. Analysis of subcellular fractions of epidermis revealed a cytoplasmic localisation in line with results of single molecule in\u00a0situ hybridisation. We report that RP11\u2010295G20.2 has a skin\u2010enriched expression, and within skin it is mainly expressed in suprabasal epidermal layers. Moreover, RP11\u2010295G20.2 is induced by the key psoriasis cytokine IL\u201017A and shows a dynamic regulation during keratinocyte differentiation with upregulation during early differentiation and downregulation in the late stage. Knockdown of RP11\u2010295G20.2 in keratinocytes promotes terminal differentiation. Based on our findings, we named RP11\u2010295G20.2\n                    <jats:styled-content>C<\/jats:styled-content>\n                    ytoplasmic\n                    <jats:styled-content>D<\/jats:styled-content>\n                    ifferentiation\u2010\n                    <jats:styled-content>A<\/jats:styled-content>\n                    ssociated Epidermal\n                    <jats:styled-content>R<\/jats:styled-content>\n                    NA, CYDAER. In summary, our study provides a comprehensive characterisation of the non\u2010coding RNA landscape of psoriasis keratinocytes and identifies CYDAER as a skin\u2010enriched lncRNA regulating keratinocyte differentiation. Our data suggest that overexpression of CYDAER may contribute to altered differentiation in psoriatic epidermis.\n                  <\/jats:p>","DOI":"10.1111\/exd.70054","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T02:45:01Z","timestamp":1739587501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["RNA Sequencing Reveals the Long Non\u2010Coding RNA Signature in Psoriasis Keratinocytes and Identifies CYDAER as a Long Non\u2010Coding RNA Regulating Epidermal Differentiation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3078-0365","authenticated-orcid":false,"given":"Jan Cedric","family":"Freisenhausen","sequence":"first","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5931-0666","authenticated-orcid":false,"given":"Longlong","family":"Luo","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8357-790X","authenticated-orcid":false,"given":"Evelyn","family":"Kelemen","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-8065","authenticated-orcid":false,"given":"Jonathan","family":"Elton","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8862-1534","authenticated-orcid":false,"given":"Viktor","family":"Skoog","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2196-1102","authenticated-orcid":false,"given":"Andor","family":"Pivarcsi","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4909-5413","authenticated-orcid":false,"given":"Enik\u00f6","family":"Sonkoly","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology, Department of Medical Sciences Uppsala University  Uppsala Sweden"},{"name":"Department of Medical Biochemistry and Microbiology Uppsala University  Uppsala Sweden"},{"name":"Division of Dermatology and Venereology, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.743180"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)32549\u20106"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.01.026"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0738\u2010081x(95)93817\u20108"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"N.Dand P. E.Stuart J.Bowes et\u00a0al. \u201cGWAS Meta\u2010Analysis of Psoriasis Identifies New Susceptibility Alleles Impacting Disease Mechanisms and Therapeutic Targets \u201dmedRxiv (2023) https:\/\/doi.org\/10.1101\/2023.10.04.23296543.","DOI":"10.1101\/2023.10.04.23296543"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392\u20100488.17.05839\u20104"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.11.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20061475"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010022\u201000566\u20108"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010019\u20100311\u20108"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000694\u20109"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010020\u201000315\u20109"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ncrna7010016"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11661"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.182121.111"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501704200"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010014\u20100570\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad1025"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx428"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010023\u201005790\u20104"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1262110"},{"key":"e_1_2_10_24_1","doi-asserted-by":"crossref","unstructured":"R.Bogle M. 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