{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:00:26Z","timestamp":1787238026028,"version":"build-2736575974"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. Due to the relatively limited understanding of HS's pathogenesis, there are currently insufficient treatment options available, and many patients' medical needs are not being met. This is partly due to the historical scarcity of ex\u00a0vivo assays and animal models that accurately recapitulate the disease. Thus, we have developed a standardised whole\u2010tissue explant model of HS to examine its pathogenic mechanisms and the efficacy of potential treatments within intact human tissue. We measured cytokine protein and RNA within whole tissue maintained in an agar\u2010media solution, finding that IL\u20106 and IL\u20108 concentrations trended upwards in both HS explants and healthy controls, while IL\u201017A, IL\u20101\u03b2, and TNF\u2010\u03b1 exhibited increases in HS tissue alone. We also show that the explants were responsive to treatment with both dexamethasone and IL\u20102. Not only do our results show that this model effectively delivers treatments throughout the explants, but they also elucidate which cytokines are related to the explant process regardless of tissue state and which are related to HS tissue specifically, laying the groundwork for future implementations of this model.<\/jats:p>","DOI":"10.1111\/exd.70057","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:38:39Z","timestamp":1739234319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Inflammatory Landscape of a Whole\u2010Tissue Explant Model of Hidradenitis Suppurativa"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9426-1133","authenticated-orcid":false,"given":"Phoebe E.","family":"Leboit","sequence":"first","affiliation":[{"name":"Department of Dermatology University of California, San Francisco (UCSF)  San Francisco California 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