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Among the air pollutants, UV radiation and particulate matter (PM) have been found among the most aggressive in terms of skin damage, inducing oxinflammatory responses, promoting degradation of extracellular matrix (ECM) components, and compromising the cutaneous defensive barrier. Topical application of technologies able to prevent oxidative damage is still one of the best approaches to protect our skin, and considering the well\u2010known antioxidant network, application of an antioxidant mixture is more recommended than a single compound. In the present study, human skin explants were exposed every day for 4\u2009days to diesel particles (DEE) or to UV after the daily pre\u2010treatment with a topical application of a commercially available antioxidant mixture (AOX Mix), containing 15% ascorbic acid, 0.5% ferulic acid and 1% tocopherol. Oxidative stress markers such as 4\u2010hydroxynonenal, skin barrier proteins such as involucrin, filaggrin, claudin\u20101 and desmocollin\u20101, resilience markers such as elastin and tropoelastin, and the levels of Type I and Type III collagens were assessed. Topical application was able to prevent most of the damage induced by the outdoor stressors, confirming that daily protection is needed to prevent cutaneous premature ageing.<\/jats:p>","DOI":"10.1111\/exd.70069","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T22:57:22Z","timestamp":1741733842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparing <scp>UV<\/scp> and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid"],"prefix":"10.1111","volume":"34","author":[{"given":"John","family":"Ivarsson","sequence":"first","affiliation":[{"name":"Department of Food, Bioprocessing and Nutrition Sciences, Plants for Human Health Institute NC State University  Kannapolis North Carolina USA"},{"name":"Department of Animal Sciences, Plants for Human Health Institute NC State University  Kannapolis North 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