{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:18:21Z","timestamp":1785248301493,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Erythrodermic psoriasis (EP) is a severe and challenging variant of psoriasis that often shows poor drug survival. While risankizumab, an IL\u201023 inhibitor, has demonstrated efficacy in patients with moderate\u2010to\u2010severe plaque psoriasis, its effectiveness in patients with a history of EP is less explored. This study aimed to evaluate treatment response to risankizumab and identify potential predictors influencing the treatment response. In this single\u2010center, longitudinal retrospective study, we included 56 patients treated with risankizumab between August 1, 2016, and June 1, 2023, of whom 22 had a history of EP. Treatment response was assessed using the Psoriasis Area and Severity Index (PASI), and the impact of patient characteristics, including prior biologic exposure and HLA\u2010Cw genotypes, on treatment response was analysed using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test. Throughout the 100\u2010week follow\u2010up, patients with a history of EP exhibited a poorer treatment response compared to those without such a history. Among patients with a history of EP, those with prior exposure to guselkumab and those treated with more than five biologics demonstrated a decreased response to risankizumab. Additionally, there was a non\u2010significant trend indicating that HLA\u2010Cw1\u2013negative patients responded better to risankizumab. This case series indicated that risankizumab might be an effective and sustainable treatment option for most patients with a history of EP. However, prior exposure to multiple biologics, particularly those with a similar mode of action targeting IL\u201023, may reduce its effectiveness. The potential association between HLA\u2010Cw1 genotype and treatment response warrants further investigation.<\/jats:p>","DOI":"10.1111\/exd.70080","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T10:26:58Z","timestamp":1741775218000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Experience of Risankizumab in Patients With a History of Erythrodermic Psoriasis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7294-3364","authenticated-orcid":false,"given":"Che\u2010Chia","family":"Hsu","sequence":"first","affiliation":[{"name":"Department of Dermatology College of Medicine, National Taiwan University Hospital, National Taiwan University Taipei Taiwan 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