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In order to study skin cell immunology under conditions which approximate the in\u00a0vivo functions, maintenance of structural tissue integrity in experimental models is essential. Consequently, several ex\u00a0vivo human models using lesional, perilesional hidradenitis suppurativa and control healthy skin, have been described, which claim to represent fast and relatively simple methods to investigate the pathophysiology of hidradenitis suppurativa and to preclinically detect the effectiveness of candidate therapeutic agents. At least some of these models seem to approximate the in\u00a0vivo situation by maintaining patients' skin architecture for several days and expressing biomarkers also detected in hidradenitis suppurativa skin in\u00a0vivo. Validation still remains to be performed for the majority of the models by evaluating the ex\u00a0vivo efficacy of drugs, which are introduced in clinical studies and\/or have been approved for HS treatment.<\/jats:p>","DOI":"10.1111\/exd.70089","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T06:55:56Z","timestamp":1744786556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hidradenitis Suppurativa Preclinical Studies: Models and Results"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos C.","family":"Zouboulis","sequence":"first","affiliation":[{"name":"European Hidradenitis Suppurativa Foundation e.V.  Dessau Germany"},{"name":"Departments of Dermatology, Venereology, Allergology and Immunology, Staedtisches Klinikum Dessau Brandenburg Medical School Theodor Fontane and Faculty of Health Sciences Brandenburg  Dessau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000431175"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16147"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.09.021"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.1677"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504370"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00022-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00101-6"},{"key":"e_1_2_5_9_1","unstructured":"Accessed December 26 2024 https:\/\/clinicaltrials.gov\/search?cond=Hidradenitis%20Suppurativa&term=Acne%20Inversa."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339773"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.14054"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18173"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.02.014"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17641"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13919"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000515955"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020619"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-022-01629-w"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2409274121"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14531"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad305"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.70057"},{"issue":"1","key":"e_1_2_5_23_1","article-title":"Unravelling Insights Into the Mechanism of Action of Secukinumab in Ameliorating the Inflammatory Phenotype of Hidradenitis Suppurativa: Lessons From Diseased Skin Organ Culture","volume":"34","author":"Edelkamp J.","year":"2025","journal-title":"Experimental Dermatology"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030100219"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14338"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14010044"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517017"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12712"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00771.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1221762"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20472"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T05:01:34Z","timestamp":1745211694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.70089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":30,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1111\/exd.70089"],"URL":"https:\/\/doi.org\/10.1111\/exd.70089","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2025-01-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70089"}}