{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:53Z","timestamp":1787014193511,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023209084"],"award-info":[{"award-number":["H2023209084"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Circulating cell\u2010free DNA (cfDNA) is a large molecule that plays a central role in the pathogenesis of SLE. It is the target antigen of autoantibodies and the main component of immune complexes. Due to the large differences in the content of cfDNA detected in different studies, cfDNA cannot be used as a strong diagnostic basis for SLE at present. As an active component of cfDNA, the correlation between double\u2010stranded DNA (dsDNA) and SLE has not been fully studied. The detection of dsDNA may provide a more accurate diagnosis and treatment basis for SLE, and the in\u2010depth study of SLE patients is helpful to further understand the pathogenesis of SLE. Blood samples were collected from 173 SLE patients and 2970 healthy controls. The concentration of serum dsDNA was determined by fluorescence quantitative method. Propensity score matching (PSM) method was used to match 444 healthy controls and 148 SLE patients according to age and gender. Serum dsDNA levels were compared between SLE patients and matched healthy controls. At the same time, blood exosomes were extracted to explore the correlation between serum dsDNA and exosome dsDNA. As demonstrated herein, serum dsDNA levels in SLE patients were shown to be considerably higher than in healthy controls. Meanwhile, In SLE patients, serum dsDNA level was correlated with season and other clinical indicators, but not with temperature and ultraviolet. Additionally, a statistically significant connection between serum and exosome dsDNA was discovered. We also found that the gene encoding the dsDNA receptor was upregulated. The presented data suggest that detection of dsDNA is promising as a rapid and simple tool for assessing disease progression in SLE, which can help physicians and patients in disease management. The mechanism of elevated dsDNA in SLE patients requires more research.<\/jats:p>","DOI":"10.1111\/exd.70102","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T08:37:31Z","timestamp":1744879051000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on the Correlation Between Double\u2010Stranded\n                    <scp>DNA<\/scp>\n                    and Systemic Lupus Erythematosus"],"prefix":"10.1111","volume":"34","author":[{"given":"Qin","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yirui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated 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Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"The Comprehensive Lab College of Basic Medicine, Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Han","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center, North China University of Science and Technology  Tangshan China"},{"name":"Inflammation and Immune Diseases Laboratory of North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9581-0502","authenticated-orcid":false,"given":"Weiwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhen","sequence":"additional","affiliation":[{"name":"North China University of Science and Technology Affiliated Hospital  Thangshan China"},{"name":"Health Science Center, North China University of Science and Technology  Tangshan China"},{"name":"Inflammation and Immune Diseases Laboratory of North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-5353","authenticated-orcid":false,"given":"Liangdan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Dermatology (Anhui Medical University) Ministry of Education  Hefei China"},{"name":"Health Science Center, North China University of Science and Technology  Tangshan China"},{"name":"Inflammation and Immune Diseases Laboratory of North China University of Science and Technology  Tangshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"issue":"4","key":"e_1_2_11_2_1","first-page":"684","article-title":"What's Wrong With Neutrophils in Lupus?","volume":"37","author":"Tsai C. 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