{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:54:38Z","timestamp":1784127278221,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T00:00:00Z","timestamp":1745366400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u201000244799"],"award-info":[{"award-number":["RS\u20102023\u201000244799"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Foreign body reaction (FBR) is an inflammatory and fibrotic reaction to degradation\u2010resistant foreign materials characterised by the temporal cascade of cellular and molecular dynamics, which remains not fully elucidated. The aim of our study was to elucidate the temporal gene expression profiles of FBR. An FBR model was generated by implanting polycaprolactone into the abdominal subcutaneous layer of C57BL\/6 mice. RNA sequencing was performed using established FBR tissues at various time points after implantation (FBR group; 2, 4, 8 and 12\u2009weeks, <jats:italic>n<\/jats:italic>\u2009=\u20094 for each time points), and normal dorsal skin of mice as the control group (<jats:italic>n<\/jats:italic>\u2009=\u20093). We identified distinct gene expression profiles between the control group and the FBR group. Extracellular matrix (ECM), immune, and epigenetics\u2010related genes were significantly enriched in the FBR group compared to normal skin. Within the FBR groups, expression profiles did not show definitive segregation across time points. We observed the highest expression of ECM\u2010related genes (<jats:italic>Adamts4<\/jats:italic>, <jats:italic>Col9a3<\/jats:italic>, <jats:italic>Col6a2<\/jats:italic>, and <jats:italic>Furin<\/jats:italic>) and pathways in the 2\u2010week samples, followed by a gradual down\u2010regulation thereafter. In conclusion, our study elucidated distinct expression profiles of FBR in comparison to normal skin, as well as the temporal expression dynamics of FBR.<\/jats:p>","DOI":"10.1111\/exd.70104","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:37:33Z","timestamp":1745458653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>RNA<\/scp> Sequencing Revealed Distinct Expression Profiles and Temporal Expression Dynamics in Murine Model of Foreign Body Reaction"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7951-8176","authenticated-orcid":false,"given":"Tae\u2010Ryong","family":"Riew","sequence":"first","affiliation":[{"name":"Department of Anatomy Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Department of Medical Sciences Graduate School, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9922-364X","authenticated-orcid":false,"given":"Ji\u2010Won","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Anatomy Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"},{"name":"Department of Medical Sciences Graduate School, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Keun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-010X","authenticated-orcid":false,"given":"Yoon\u2010Seob","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Seoul Republic of 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