{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T22:07:25Z","timestamp":1769119645955,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3602002"],"award-info":[{"award-number":["2022YFC3602002"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease characterised by oxidative stress in the epidermis. Riboflavin (vitamin B2), an essential vitamin with antioxidant properties, may play a role in modulating this condition. Using data from three cycles of the National Health and Nutrition Examination Survey (NHANES), we analysed 13\u2009825\u2009U.S. citizens, including 409 (2.96%) cases of psoriasis. A fully adjusted weighted logistic regression model revealed that psoriasis was associated with decreased riboflavin intake: for each natural\u2010log unit increase in riboflavin intake, the risk of psoriasis decreased by an average of 16% (OR: 0.84, 95% CI: 0.73\u20130.96). This association was particularly significant among middle\u2010aged and elderly people (&gt;\u200940\u2009years). Transcriptome analysis of data series GSE41662 and GSE121212 demonstrated upregulation of riboflavin metabolising genes (SLC52A2, SLC52A3, RFK, FLAD1 and SLC25A32) in psoriatic lesional skin. In an in\u00a0vitro psoriatic keratinocyte model, riboflavin reduction induced upregulation of inflammatory cytokines, ROS response and delayed keratinisation. These findings indicate that psoriasis is significantly associated with decreased riboflavin intake, and riboflavin metabolism is activated in psoriasis. The protective effect of riboflavin on psoriasis merits further attention.<\/jats:p>","DOI":"10.1111\/exd.70106","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:13:01Z","timestamp":1746187981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Riboflavin Deficiency Associated With Psoriasis: Insights From Population and Transcriptome"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8553-8816","authenticated-orcid":false,"given":"Ang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feilong","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Research and Biometrics Center, National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyue","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"},{"name":"Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Changhai Hospital, the Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingkai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejiao","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences &amp; School of Basic Medicine Peking Union Medical College  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Dermatology China\u2010Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2021.2007"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32549-6"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2827"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.1412"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21718"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.09.020"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.07.165"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2023.103408"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2018.2127"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.0357"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189149"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16926"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.84077"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.04.010"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2016.10.002"},{"key":"e_1_2_14_17_1","unstructured":"Webpage NCFS \u201cNHANES Questionnaire Datasets and Related Documentation \u201d2024(01\/04) https:\/\/wwwn.cdc.gov\/nchs\/nhanes\/Default.aspx."},{"key":"e_1_2_14_18_1","unstructured":"Webpage NCFS \u201cNCHS Ethics Review Board (ERB) Approval \u201d2024(01\/04) https:\/\/www.cdc.gov\/nchs\/nhanes\/irba98.htm."},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2022.1609"},{"key":"e_1_2_14_20_1","unstructured":"NHANES \u201c2009\u20132010 Data Documentation Codebook and Frequencies \u201d(2013) 2024 (01\/04)."},{"key":"e_1_2_14_21_1","unstructured":"U.S. Department of Agriculture Agricultural Research Service \u201cUSDA Food and Nutrient Database for Dietary Studies 5.0. 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