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Immunohistochemical analysis revealed elevated phosphorylated Janus kinase (p\u2010JAK)1 and p\u2010JAK2 expression in PV lesions, complemented by transcriptome data showing JAK\/STAT pathway dysregulation. Using a PV acantholysis model, we demonstrated that Ruxolitinib, a JAK1\/2 inhibitor, significantly reduced keratinocyte apoptosis, enhanced cell adhesion,\u00a0and alleviated endoplasmic reticulum (ER) stress. Additionally, Ruxolitinib mitigated tunicamycin\u2010induced ER stress and apoptosis in HaCaT cells. These findings establish a crucial role for JAK1\/2 in PV pathogenesis, demonstrating that their inhibition alleviates ER stress, reduces apoptosis, and improves cell adhesion. Our results provide a theoretical foundation for the clinical application of JAK inhibitors in PV treatment.<\/jats:p>","DOI":"10.1111\/exd.70121","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T13:45:37Z","timestamp":1747748737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<scp>JAK1<\/scp>\/2 Inhibitors Alleviate the Damage of Intercellular Adhesion by Reducing Endoplasmic Reticulum Stress\u2010Induced Apoptosis in Pemphigus Vulgaris"],"prefix":"10.1111","volume":"34","author":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Nian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nanfang Hospital, Southern Medical University  Guangzhou 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