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Previous observational studies have shown that patients with psoriasis are predisposed to cardiovascular comorbidities, but few studies have investigated the impact of psoriasis\u2010related chronic inflammation on cardiac function. In this study, we used imiquimod (IMQ) to establish psoriasis\u2010like mouse models with short\u2010term inflammation (IMQ\u2010ST) or long\u2010term repeated inflammation (IMQ\u2010LT), to mimic acute or chronic recurrent pathophysiology of psoriasis inflammation. The inflammatory pattern in the hearts of IMQ\u2010ST mice and IMQ\u2010LT mice was similar to that in the skin, characterised by increased level of interleukin (IL)\u201017A and proportion of IL\u201017A\u2010producing \u03b3\u03b4T cells. However, only IMQ\u2010LT mice showed declined cardiac function, significant myocardial tissue necrosis, and decreased expression of genes encoding structural and functional proteins in cardiomyocytes. Furthermore, IL\u201017A neutralisation markedly alleviated myocardial injury and improved cardiac function in IMQ\u2010LT mice. In conclusion, we demonstrated that IL\u201017A\u2010mediated inflammation was present in the skin and heart of acute and chronic psoriasis\u2010like mouse models. However, only IMQ\u2010LT mice developed myocardial injury and declined cardiac function, which could be prevented by IL\u201017A neutralisation.<\/jats:p>","DOI":"10.1111\/exd.70139","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T12:50:23Z","timestamp":1753188623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u201017A\u2010Related Inflammation Mediates Cardiac Injury in Chronic Relapsing Psoriasis\u2010Like Mouse Model"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6217-5146","authenticated-orcid":false,"given":"Mengyan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Ruijin Hospital School of Medicine, Shanghai Jiaotong University  Shanghai People's Republic of 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