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Although\n                    <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>\n                    demonstrates potential for psoriasis therapy, its underlying mechanism remains insufficiently understood. In this study, various\n                    <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>\n                    constituents were evaluated in an imiquimod (\n                    <jats:styled-content style=\"fixed-case\">IMQ<\/jats:styled-content>\n                    )\u2010induced mouse model of psoriasis.\n                    <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>\n                    , platelet\u2010derived extracellular vesicles (\n                    <jats:styled-content style=\"fixed-case\">PEVs<\/jats:styled-content>\n                    ), and platelet\u2010poor plasma (\n                    <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content>\n                    ) were isolated from mice and administered subcutaneously. The data showed that\n                    <jats:styled-content style=\"fixed-case\">PEVs<\/jats:styled-content>\n                    , rather than\n                    <jats:styled-content style=\"fixed-case\">PPP<\/jats:styled-content>\n                    , served as the principal anti\u2010psoriatic factor. Furthermore,\n                    <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\n                    sequencing and flow cytometry revealed that\n                    <jats:styled-content style=\"fixed-case\">PEVs<\/jats:styled-content>\n                    markedly suppressed\n                    <jats:styled-content style=\"fixed-case\">M1<\/jats:styled-content>\n                    polarisation of macrophages, thereby mitigating psoriatic\u2010like inflammation. In\u00a0vitro,\n                    <jats:styled-content style=\"fixed-case\">PEVs<\/jats:styled-content>\n                    delivered encapsulated mitochondria to\n                    <jats:styled-content style=\"fixed-case\">RAW264<\/jats:styled-content>\n                    .7 cells in a concentration\u2010dependent manner. These functional organelles enhanced oxidative phosphorylation and suppressed glycolysis, driving a metabolic shift favouring an anti\u2010inflammatory phenotype and attenuating the inflammatory response. In conclusion,\n                    <jats:styled-content style=\"fixed-case\">PEVs<\/jats:styled-content>\n                    emerge as the primary\n                    <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>\n                    component responsible for inflammatory suppression in psoriasis. Notably, mitochondria transfer mediated by\n                    <jats:styled-content style=\"fixed-case\">PEVs<\/jats:styled-content>\n                    underscores a promising therapeutic avenue and provides novel insight into the role of platelet derivatives in inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1111\/exd.70152","type":"journal-article","created":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T07:16:06Z","timestamp":1755414966000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Platelet\u2010Derived Extracellular Vesicles Alleviate Psoriatic Inflammation via Mitochondrial Transfer to Macrophages"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-4798","authenticated-orcid":false,"given":"Bing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, School of Medicine Shanghai Jiao Tong 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4974-8012","authenticated-orcid":false,"given":"Yijun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Institute of Dermatology, School of Medicine Shanghai Jiao Tong University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6954-5899","authenticated-orcid":false,"given":"Haifei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Xinhua Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Institute of Dermatology, School of Medicine Shanghai Jiao Tong University  Shanghai 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