{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:20:32Z","timestamp":1792797632720,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["2022MZEEZB (CUPE53D23013260006)"],"award-info":[{"award-number":["2022MZEEZB (CUPE53D23013260006)"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Negative pigment network (NPN) is a dermoscopic structure frequently associated with melanoma. Though commonly observed in Spitz naevi (SN) and Spitzoid melanoma (SM), its reflectance confocal microscopy (RCM) correlates have been primarily studied in non\u2010Spitzoid melanocytic neoplasms. This study aimed to identify clinical, dermoscopic, and RCM features associated with dermoscopic NPN in Spitzoid neoplasms and explore its histopathological correlates. We retrospectively analysed clinical, dermoscopic, and RCM images from 128 histopathologically confirmed SN and SM cases diagnosed between 2014 and 2020. Lesions were grouped by presence or absence of dermoscopic NPN, and comparisons were made across clinical, dermoscopic, and RCM features. A subset of 20 cases underwent histopathologic correlation. Of the 128 cases, 96 (74%) were SN and 32 (26%) SM. NPN was present in 58 lesions (45%)\u201440 SN (42%) and 18 SM (56%). NPN was associated with lesion diameter \u2265\u20095\u2009mm, presence of shiny white structures, dotted vessels, and inversely associated with diffuse blue\u2010white veil. SMs showed higher frequencies of asymmetry, multicomponent patterns, and extensive NPN. RCM features previously linked to NPN\u2014round or linear surface disruptions, bright suprabasal areas, and broadened interpapillary spaces\u2014were seen in 87% of cases but did not correlate with diagnosis or dermoscopic NPN. Corresponding histologic features included keratin\u2010filled dells, hypergranulosis, and broadened rete ridges or infundibula. RCM correlates of dermoscopic NPN are frequently observed in Spitzoid neoplasms, independent of visible dermoscopic NPN, suggesting perceptibility may depend on contrast within dermoscopic patterns.<\/jats:p>","DOI":"10.1111\/exd.70154","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T10:49:27Z","timestamp":1756291767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Clinical, Dermoscopic and Reflectance Confocal Microscopy Characteristics Associated With the Presence of Negative Pigment Network Among Spitzoid Neoplasms"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-4222","authenticated-orcid":false,"given":"Marco","family":"Spadafora","sequence":"first","affiliation":[{"name":"Department of Surgery, Medicine, Dental Medicine and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Azienda Unit\u00e0 Sanitaria Locale\u2014IRCCS di Reggio Emilia Skin Cancer Center  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Farnetani","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Borsari","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dental Medicine and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaniko","family":"Kaleci","sequence":"additional","affiliation":[{"name":"Azienda Unit\u00e0 Sanitaria Locale\u2014IRCCS di Reggio Emilia Skin Cancer Center  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafi","family":"Porat","sequence":"additional","affiliation":[{"name":"The Kittner Skin Cancer Screening &amp; Research Institute, Sheba Medical Center, Ramat Gan and School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Ciardo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignazio","family":"Stanganelli","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit IRCCS Istituto Romagnolo per Lo Studio Dei Tumori (IRST) \u2018Dino Amadori\u2019  Meldola Italy"},{"name":"Dermatology Unit, Department of Clinical and Experimental Medicine University of Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Longo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medicine, Dental Medicine and Morphological Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Dermatology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[{"name":"Dermatology Clinic, Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Scope","sequence":"additional","affiliation":[{"name":"The Kittner Skin Cancer Screening &amp; 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