{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:10:31Z","timestamp":1792631431015,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["113\u2010SCN0005"],"award-info":[{"award-number":["113\u2010SCN0005"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["PC1451"],"award-info":[{"award-number":["PC1451"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Radiation dermatitis is a common side effect of radiotherapy, affecting up to 95% of cancer patients receiving radiation therapy and often leading to skin damage, inflammation, and ulceration. The pathogenesis of radiation dermatitis involves complex mechanisms, such as the production of reactive oxygen species (ROS) and sustained inflammatory responses. Current treatments, including topical steroids, moisturisers, and non\u2010steroidal anti\u2010inflammatory drugs (NSAIDs), often provide limited efficacy, primarily addressing symptoms rather than the underlying pathophysiological processes. In this study, we evaluated the therapeutic potential of rice bran extract (RBE) in mitigating radiation\u2010induced skin injury. High\u2010performance liquid chromatography (HPLC) analysis revealed that RBE is rich in bioactive compounds, including pyrogallol, gallic acid, and ferulic acid, known for their antioxidant and anti\u2010inflammatory properties. In\u00a0vitro assays demonstrated that RBE exhibited fair biocompatibility, reduced IL\u20106 production, enhanced 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) radical scavenging activity, stimulated procollagen synthesis, and promoted fibroblast migration. In a murine dorsal skin irradiation model, topical RBE application alleviated dermatitis severity, reduced skin ulceration, minimised histological signs of inflammation and fibrosis, and promoted epithelial regeneration. Bulk RNA sequencing revealed that RBE modulated key pathways related to inflammation resolution, epidermal repair, and metabolic adaptation, with\n                    <jats:italic>Pparg<\/jats:italic>\n                    identified as a central upstream regulator. Overall, RBE demonstrates antioxidant, anti\u2010inflammatory, and pro\u2010regenerative activities that support its potential for preventing and treating radiation dermatitis.\n                  <\/jats:p>","DOI":"10.1111\/exd.70162","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T06:47:49Z","timestamp":1757400469000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rice Bran Extract Alleviates Inflammation and Promotes Wound Healing in Radiation Dermatitis"],"prefix":"10.1111","volume":"34","author":[{"given":"Chen\u2010Hsiang","family":"Kuan","sequence":"first","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery National Taiwan University Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Research Center for Developmental Biology and Regenerative Medicine National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takatori","family":"Hideki","sequence":"additional","affiliation":[{"name":"Medein Science Corporation  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun\u2010Ho","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin\u2010Jui","family":"Kung","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Department of Surgery National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Jan","family":"Lin","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Medicine, College of Medicine National Taiwan University  Taipei Taiwan"},{"name":"Research Center for Developmental Biology and Regenerative Medicine National Taiwan University  Taipei Taiwan"},{"name":"Department of Biomedical Engineering National Taiwan University  Taipei Taiwan"},{"name":"Department of Medical Research National Taiwan University Hospital  Taipei Taiwan"},{"name":"Center for Frontier Medicine National Taiwan University Hospital  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherng\u2010Kang","family":"Perng","sequence":"additional","affiliation":[{"name":"Department of Surgery Chang Bing Show Chwan Memorial Hospital  Lukang Taiwan"},{"name":"Division of Plastic and Reconstructive Surgery, Department of Surgery Taipei Veterans General Hospital  Taipei Taiwan"},{"name":"Department of Surgery National Yang Ming Chiao Tung University School of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.09.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/11795549211036898"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2020.01.009"},{"issue":"22","key":"e_1_2_11_5_1","article-title":"Radiation\u2010Induced Skin Injury: Pathogenesis, Treatment, and Management","volume":"12","author":"Yang X.","year":"2020","journal-title":"Aging (Albany 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