{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:28:19Z","timestamp":1788362899708,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T00:00:00Z","timestamp":1758672000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"publisher","award":["23385"],"award-info":[{"award-number":["23385"]}],"id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emerging evidence supports the neurogenic origin of psoriasis, yet the morphology and distribution of nerve fibres in psoriatic skin remain poorly characterised due to methodological inconsistencies and limited 3D data. The aim of this study was to provide a comprehensive 3D quantification of nerve fibre morphology in psoriatic skin and assess its spatial relation to vasculature and clinical parameters. High\u2010resolution confocal microscopy was used to analyse 69 (70\u2009\u03bcm thick) skin sections from 23 psoriasis patients, capturing full\u2010thickness epidermis and dermis. Nerve fibres were segmented by location (epidermal, papillary and reticular) and quantified volumetrically alongside vascular networks. The results show that nerve fibres occupied ~0.1% of total skin volume and predominantly localised near vasculature in the dermis, with epidermal nerves branching from perivascular plexuses. Epidermal nerve fibre volume negatively correlated with erythema, age and epidermal thickness (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). No significant correlation was observed between dermal nerve fibre volumes and vascular density or clinical severity scores. This study presents a detailed 3D neurovascular map of psoriatic skin, revealing a distinct topography of nerve\u2010vessel relationships. The findings highlight that epidermal nerve fibres (not total nerve density) show the strongest association with clinical markers. These results provide a critical baseline for evaluating nerve\u2010targeted therapies and modelling neurovascular responses in laser\u2010based psoriasis treatments.\n                  <\/jats:p>","DOI":"10.1111\/exd.70166","type":"journal-article","created":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T04:38:26Z","timestamp":1758775106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nerve Fibres in Psoriatic Skin and Their Relation to Vasculature and Clinical Parameters"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2217-7742","authenticated-orcid":false,"given":"Meagan","family":"Doppegieter","sequence":"first","affiliation":[{"name":"Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3535-6256","authenticated-orcid":false,"given":"Nick","family":"van der Beek","sequence":"additional","affiliation":[{"name":"Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"ZBC Multicare  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice C. G.","family":"Aalders","sequence":"additional","affiliation":[{"name":"Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Personalized Medicine Amsterdam Public Health  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik N. T. P.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"},{"name":"Neurovascular Disorders Amsterdam Neuroscience  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Neumann","sequence":"additional","affiliation":[{"name":"ZBC Multicare  Hilversum the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ton G.","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Biomedical Engineering and Physics Amsterdam UMC, University of Amsterdam  Amsterdam the Netherlands"},{"name":"Heart Failure and Arrhythmias Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"},{"name":"Atherosclerosis &amp; Ischemic Syndromes Amsterdam Cardiovascular Sciences  Amsterdam the Netherlands"},{"name":"Imaging and Biomarkers Cancer Center Amsterdam  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(86)70034-0"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb03825.x"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1991.tb05870.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155598433368"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030100224"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371778"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05586.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-016-0183-7"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00477080"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00422"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(02)00103-2"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.1997.11"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050249"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep13071340"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00371926"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050340"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.058"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.23781"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:HUMP.0000013769.49991.5c"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469898"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0079\u20106123(03)46027\u20105"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2007.08.013"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.05.021"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01984"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070710"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0265"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7489316"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10347.x"}],"container-title":["Experimental 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