{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:19:40Z","timestamp":1784027980053,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>As hyperpigmentation can worsen with exposure to ultraviolet (UV) and visible light (VL), sunscreens with well\u2010balanced UVB\/UVA protection and VL\u2010blocking pigments are recommended. Assessing efficiency against VL\u2010induced pigmentation is then mandatory. Recently, an in\u00a0vivo pigmentation assessment allowing a VL protection factor (pVL\u2010PF) determination, and an in\u00a0vitro predictive method based on transmittance measures were introduced. However, the number of volunteers, tested sunscreens, and protection range were limited. Moreover, no statistical assessment was associated. This study aimed at testing the robustness and improving these methodologies by conducting a series of 9 monocentric, double\u2010blind, randomised controlled in\u00a0vivo studies involving 188 volunteers and 30 products, alongside an in\u00a0vitro approach, in 2 independent laboratories. Our results first allowed us to improve pVL\u2010PF calculation by better fitting to VL\u2010induced pigmentation dynamics. Based on the 30 established pVL\u2010PF, we evidenced that VL\u2010protection level strongly correlated with the amount of pigments in products. Second, a statistical Bayesian approach, accounting for kinetic and inter\u2010individual response variability over time, was proposed. This enabled us to determine that 24 out of 30 products significantly reduced VL\u2010induced pigmentation. Finally, we showed that in\u00a0vitro transmittance reduction was highly predictive of in\u00a0vivo results. In conclusion, through several independent studies involving a large number of products and volunteers, a refined pVL\u2010PF calculation associated with statistical indicators was proposed together with a predictive in\u00a0vitro assessment. These methodologies to assess the efficacy of tinted products against VL\u2010induced pigmentation are complementary and could also be of interest for other pathologies induced or aggravated by VL.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    NCT06827392, NCT06796192, NCT06803901, NCT06796140, NCT06796153, NCT06796010, NCT06796088, NCT06796205, NCT06796179\n                  <\/jats:p>","DOI":"10.1111\/exd.70167","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T06:45:06Z","timestamp":1757400306000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Visible Light\u2010Induced Pigmentation: Improved In\u00a0Vivo Methodology for Measuring Efficacy of 30 Products in 9 Randomised Controlled Trials and Correlation With In\u00a0Vitro Assessment"],"prefix":"10.1111","volume":"34","author":[{"given":"Pascale","family":"Renoux","sequence":"first","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Chevilly Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4641-3161","authenticated-orcid":false,"given":"Hussein","family":"Jouni","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0714-7077","authenticated-orcid":false,"given":"Cl\u00e9ment","family":"Laloux","sequence":"additional","affiliation":[{"name":"Cencora\u2010PharmaLex Belgium  Mont\u2010Saint\u2010Guibert Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Touti","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Chevilly Larue France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane\u2010Lore","family":"Vieu","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lamarche","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Morim","family":"Santos","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Bernerd","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-2001","authenticated-orcid":false,"given":"Claire","family":"Marionnet","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research and Innovation  Aulnay sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S207256"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12325"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2008.00384.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.274"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20143063"},{"key":"e_1_2_11_7_1","article-title":"Pigmentary Disorders Around the World: Self\u2010Reported Prevalence and Impact on Quality of Life and Social Stigmatization. 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