{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:59:10Z","timestamp":1787165950785,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100024738","name":"Chulabhorn International College of Medicine, Thammasat University","doi-asserted-by":"publisher","award":["T 2\/2566"],"award-info":[{"award-number":["T 2\/2566"]}],"id":[{"id":"10.13039\/501100024738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024738","name":"Chulabhorn International College of Medicine, Thammasat University","doi-asserted-by":"publisher","award":["T3\/2561"],"award-info":[{"award-number":["T3\/2561"]}],"id":[{"id":"10.13039\/501100024738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Exosomes are nanosized extracellular vesicles that mediate intercellular communication by transferring bioactive molecules. Mesenchymal stem cells (MSCs) from different tissue sources secrete exosomes with potentially distinct therapeutic properties. In this study, we compared the anti\u2010inflammatory efficacy of exosomes derived from human adipose\u2010derived MSCs (hADMSCs\u2010EXOs) and human umbilical cord\u2010derived MSCs (hUCMSCs\u2010EXOs), together with desoximetasone (DSM), in an imiquimod\u2010induced psoriasis mouse model. Psoriasiform lesions were induced, and treatment outcomes were assessed through clinical, histological, and immunological assessments. Both hADMSCs\u2010EXOs and hUCMSCs\u2010EXOs significantly attenuated psoriasiform lesions, as clinically evidenced by reduced cumulative Psoriasis Severity Index (PSI) scores by day 6 of treatment. Notably, hUCMSCs\u2010EXOs and DSM significantly reduced epidermal and dermal thickness to no significant difference compared to the control group. Immune cell infiltration, including CD3\n                    <jats:sup>+<\/jats:sup>\n                    , CD4\n                    <jats:sup>+<\/jats:sup>\n                    , CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, CD68\n                    <jats:sup>+<\/jats:sup>\n                    macrophages, CD117\n                    <jats:sup>+<\/jats:sup>\n                    mast cells, and neutrophils, was also markedly reduced in the hUCMSCs\u2010EXOs and DSM groups. Importantly, unlike DSM, hUCMSCs\u2010EXOs did not induce skin thinning or systemic adverse effects. Growth factor (GF) profiling revealed that hADMSCs\u2010EXOs were enriched in FGFs, PDGFs, and VEGF, whereas hUCMSCs\u2010EXOs contained higher levels of HGF, a key modulator of immunoregulation and tissue repair. Collectively, these findings suggest that MSC\u2010derived exosomes exert therapeutic effects through both anti\u2010inflammatory and regenerative mechanisms, with hUCMSCs\u2010EXOs demonstrating superior anti\u2010inflammatory efficacy over hADMSCs\u2010EXOs and a lower likelihood of inducing local or systemic adverse effects compared with DSM. Given the influence of MSC\u00a0tissue origin on exosome content and function, our results support the potential of hUCMSCs\u2010EXOs as a promising steroid\u2010sparing therapeutic approach for psoriasis.\n                  <\/jats:p>","DOI":"10.1111\/exd.70176","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:06:41Z","timestamp":1762866401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exosome\u2010Based Therapy: A Comparative Study of Adipose\u2010 and Umbilical Cord\u2010Derived Mesenchymal Stem Cells\u2010Derived Exosomes in Psoriatic Mouse Model"],"prefix":"10.1111","volume":"34","author":[{"given":"Rueangrit","family":"Siriphanit","sequence":"first","affiliation":[{"name":"Division of Dermatology, Chulabhorn International College of Medicine Thammasat University  Pathum Thani 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