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Despite significant advancements in biologic therapies for psoriasis skin lesions, the lack of specific recommendations in current clinical guidelines for managing psoriasis with cardiovascular comorbidities has left the burden of these comorbidities continuing to significantly impair patients' quality of life and impose a substantial economic strain on society. Platelets, as unique cells with dual roles in haemostasis and inflammation, are critically involved in both psoriatic disease and its cardiovascular comorbidities. Recent evidence suggests that combining antiplatelet agents with biologic therapy may be a promising strategy for treating psoriatic patients with coexisting cardiovascular diseases. 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Current clinical guidelines and ongoing GCP trials lack relevant data on this approach; advancing this strategy could yield valuable evidence for future recommendations.<\/jats:p>","DOI":"10.1111\/exd.70177","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:11:44Z","timestamp":1762866704000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combination of Antiplatelet Therapy in Psoriatic Diseases With Cardiovascular Comorbidities: A Thromboinflammatory Perspective in the Era of Biologic Therapies"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2906-5081","authenticated-orcid":false,"given":"Ling","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Daping Hospital Army Medical University  Chongqing 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