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Its pathogenesis involves complex interactions among genetic predisposition, environmental factors, and autoimmune dysregulation. In recent years, extensive research has highlighted the critical role of epigenetic regulation in vitiligo development, including aberrant DNA methylation, dysregulated histone modifications, and non\u2010coding RNA (ncRNA) expression disturbances. These abnormal epigenetic modifications contribute to disease progression by disrupting melanogenesis, promoting oxidative stress\u2013induced melanocyte apoptosis, and driving autoimmune responses. From a translational perspective, specific epigenetic alterations show potential as diagnostic biomarkers, disease severity indicators, and therapeutic response monitors. Furthermore, epigenetic drugs, CRISPR\/dCas9\u2010based epigenetic editing, and targeted epigenetic reprogramming of tissue\u2010resident memory T cells demonstrate promising clinical applications. This review systematically summarises the molecular mechanisms underlying epigenetic dysregulation in vitiligo pathogenesis and explores its translational implications, providing a theoretical foundation for advancing disease understanding and developing novel therapeutic strategies.<\/jats:p>","DOI":"10.1111\/exd.70178","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:29:38Z","timestamp":1763425778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitiligo and Epigenetics: From Pathogenesis to Clinical Applications"],"prefix":"10.1111","volume":"34","author":[{"given":"Huimin","family":"He","sequence":"first","affiliation":[{"name":"Department of Dermatology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases  Beijing 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