{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:23:49Z","timestamp":1790285029074,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["M\u20102022\u2010C1485\u201000004"],"award-info":[{"award-number":["M\u20102022\u2010C1485\u201000004"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","award":["RS\u20102024\u201000407544"],"award-info":[{"award-number":["RS\u20102024\u201000407544"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dry skin (xerosis) often involves skin barrier disruption, especially after laser treatment. Moisturisers are crucial for managing dry skin, yet optimal formulations for skin barrier recovery are limited. This study aims to evaluate the effectiveness of a novel moisturiser containing an AIMP1\u2010derived peptide (AdP) in alleviating xerosis after laser treatment and to investigate its effect on skin barrier disruption in\u00a0vitro. In our randomised controlled clinical trial, we measured transepidermal water loss (TEWL) and Investigative Global Assessment (IGA) scores in participants using AdP\u2010containing moisturisers (ADMP group) versus other moisturisers (CTRL group). The ADMP group demonstrated significant TEWL reduction and improved IGA scores without complications. In\u00a0vitro study showed that TNF\u2010\u03b1 levels increased in laser\u2010irradiated skin compared to non\u2010irradiated skin. TNF\u2010\u03b1 treatment on HaCaT cells disrupted tight junction function, which was rescued by AdP treatment. Additionally, TNF\u2010\u03b1 affected tight junction proteins ZO\u20101 and occludin even at very low doses. TNF\u2010\u03b1 treatment upregulated the downstream signalling proteins TRAF2 and NF\u2010kB, and this effect was mitigated by AdP treatment. Our findings suggest that AdP\u2010containing moisturisers enhance skin barrier function and effectively manage xerosis after laser treatment. These results highlight AdP's potential as a therapeutic cosmeceutical ingredient for treating irradiated and post\u2010procedural dry skin.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT05982509\n                  <\/jats:p>","DOI":"10.1111\/exd.70183","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T07:01:00Z","timestamp":1765177260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Attenuation of Subclinical\n                    <scp>TNF<\/scp>\n                    \u2010\u03b1 Signalling in Xerotic Skin by\n                    <scp>AIMP<\/scp>\n                    \u20101 Derived Peptide Containing Moisturiser Leads to Skin Barrier Recovery"],"prefix":"10.1111","volume":"34","author":[{"given":"Yul Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Jin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9558-4990","authenticated-orcid":false,"given":"Han Seul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4756-8395","authenticated-orcid":false,"given":"Sun Woo","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoseob","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Ajou University School of Medicine  Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Joon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon 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