{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T13:30:17Z","timestamp":1786800617070,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Atopic dermatitis (AD) is a chronic inflammatory skin disease with high heritability, yet its genetic basis, especially in non\u2010European populations, is not fully elucidated. To identify genetic variants associated with AD and to evaluate polygenic risk scores (PRS) for predicting AD risk, severity, and serum IgE levels in a Taiwanese Han population. We conducted a genome\u2010wide association study (GWAS) using data from the China Medical University Hospital Biobank (1031\n                    <jats:sc>AD<\/jats:sc>\n                    cases, 2106 controls). Two PRS models were developed: PRS_AD (AD risk) and PRS_IgE (IgE levels). The cohort was split into discovery and replication sets (8:2 ratio). Logistic regression, adjusted for age, sex, and population stratification, was used. The GWAS identified a novel AD\u2010associated locus: rs905307 in\n                    <jats:italic>RANBP2<\/jats:italic>\n                    (OR\u2009=\u20090.66,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20092.75\u2009\u00d7\u200910\n                    <jats:sup>\u22128<\/jats:sup>\n                    ). PRS_IgE was significantly associated with increased AD risk (OR\u2009=\u20092.230, 95% CI\u2009=\u20091.815\u20132.741,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and correlated with serum IgE levels (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.168,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Patients requiring systemic treatment for severe AD had significantly higher PRS_IgE scores (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.017). This study identified a novel genetic locus associated with AD and highlights a shared genetic basis between IgE levels and AD. PRS_IgE demonstrates potential for predicting AD risk and severity, suggesting opportunities for early intervention and personalized management in the Taiwanese Han population. Further research is needed to confirm these findings and explore clinical applications.\n                  <\/jats:p>","DOI":"10.1111\/exd.70187","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T05:56:01Z","timestamp":1765432561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Variants and Polygenic Risk Scores Linked to Atopic Dermatitis Risk, Severity, and Serum\n                    <scp>IgE<\/scp>\n                    Levels"],"prefix":"10.1111","volume":"34","author":[{"given":"Chang\u2010Ching","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Children's Hospital China Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Ling","family":"Liao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine China Medical University  Taichung Taiwan"},{"name":"Center for Personalized Medicine, Department of Medical Research China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsing\u2010Fang","family":"Lu","sequence":"additional","affiliation":[{"name":"Million\u2010Person Precision Medicine Initiative, Department of Medical Research China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7302-8248","authenticated-orcid":false,"given":"Jai\u2010Sing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, China Medical University Hospital China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Ya\u2010Wen","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integrated Medicine, College of Chinese Medicine China Medical University  Taichung Taiwan"},{"name":"Center for Personalized Medicine, Department of Medical Research China Medical University Hospital  Taichung Taiwan"},{"name":"Genetic Center, Department of Medical Research China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5175-908X","authenticated-orcid":false,"given":"Su\u2010Boon","family":"Yong","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Children's Hospital China Medical University Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5074-2130","authenticated-orcid":false,"given":"Hao\u2010Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Medicine China Medical University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiu\u2010Yao","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, Children's Hospital China Medical University Hospital  Taichung Taiwan"},{"name":"School of Medicine China Medical University  Taichung Taiwan"},{"name":"Center of Allergy, Immunology and Microbiome (AIM), Department of Allergy and Immunology China Medical University Children's Hospital  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1373-245X","authenticated-orcid":false,"given":"Fuu\u2010Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Genetic Center, Department of Medical Research China Medical University Hospital  Taichung Taiwan"},{"name":"School of Chinese Medicine, College of Chinese Medicine China Medical University  Taichung Taiwan"},{"name":"Department of Medical Genetics China Medical University Children's Hospital  Taichung Taiwan"},{"name":"Department of Medical Laboratory Science and Biotechnology Asia University  Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13\u2010RAI\u20100564"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.943640"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.11.019"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/902359"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223\u2010016\u20100158\u20105"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.04.019"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz175"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2019.10.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201041180\u20102"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2024.109897"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt0539"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.37796\/2211\u20108039.1302"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13742\u2010015\u20100047\u20108"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giz082"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.029"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.71"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016\u2010011\u20108252\u20104"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0156077"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20102165"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063\u2010017\u20101809\u20107"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.15245"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2023.103096"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15173"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047472\u20105"}],"container-title":["Experimental 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