{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T13:25:49Z","timestamp":1793453149642,"version":"4.5.0"},"reference-count":60,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Advancing age is associated with an increasing prevalence of dry skin conditions such as xerosis, asteatotic eczema and atopic dermatitis (AD). Although broad changes in stratum corneum (SC) lipids and AD history have been implicated, age\u2010related alterations in the SC lipidome within at\u2010risk populations remain unclear. We characterised SC structure and lipidomic profiles in 58 adults with dry, eczema\u2010prone skin across a wide age range. Assessments included visual dryness, biophysical properties (TEWL, capacitance, skin\u2010surface\u2010pH), irritant sensitivity, ATR\u2010FTIR spectroscopy and lipidomic analysis through quantification of extracted SC lipids via mass spectrometry. Age correlated significantly with increased dryness (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.46,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.0001) and reduced hydration (r\u2009=\u2009\u22120.42,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.0001). Spectroscopy revealed declines in total lipids (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0026), water (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0009), lipid esters (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) and carboxylates (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0004) with age. Among 1385 quantified lipid species, triacylglycerol (TAG) was most abundant; TAG 46:1;0 associated with dryness (r\u2009=\u2009\u22120.42,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.0001). Ceramides CER[AH] (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), CER[AP] (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), CER[AdS] (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.042), CER[NP] (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031) and CER[NdS] (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) all significantly increased with age relative to protein. Notably, CER[NdS] species shifted towards shorter (16\u00baC) acyl chains (+2.23%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.01) and away from longer (24\u00baC) chains (\u22123.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). The CER[NdS]\/CER[NH] ratio correlated with age (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.59,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001), dryness (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.36,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0006), and barrier integrity (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.59,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001) (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009\u2264\u20090.0006). Within an at\u2010risk population, SC lipid levels change as the skin ages. These changes, especially an increase in short acyl chain NdS ceramides, were associated with the decline in skin barrier function and may help explain the increased prevalence of xerosis and the (re)emergence of eczema in later life.\n                  <\/jats:p>","DOI":"10.1111\/exd.70192","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T05:46:31Z","timestamp":1766036791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Impact of Age on the Lipidomic Profile of the Stratum Corneum and Associated Effects on Structure, Function and Overall Skin Health in Adults Predisposed to Atopic Dermatitis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1296-0098","authenticated-orcid":false,"given":"S. F.","family":"Williams","sequence":"first","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Andrew","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Brown","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Chittock","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pinnock","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Poyner","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Cork","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"},{"name":"The Paediatric Dermatology Clinic Sheffield Children's Hospital  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Danby","sequence":"additional","affiliation":[{"name":"Sheffield Dermatology Research, Division of Clinical Medicine, School of Medicine &amp; Population Health University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000334631"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258219"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18652"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04197-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2020.1754706"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/la4037474"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360009"},{"issue":"4","key":"e_1_2_11_9_1","first-page":"729","article-title":"Topical Supplementation With Physiologic Lipids Rebalances the Stratum Corneum Ceramide Profile and Strengthens Skin Barrier Function in Adults Predisposed to Atopic Dermatitis","volume":"193","author":"Andrew P. V.","year":"2025","journal-title":"Review\u2010Pending"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1995.tb00029.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100235"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp9718109"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20955"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312641"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13784"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19831"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117919"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12373"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000231524"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750042943"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12024"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-012-1313-6"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.15308"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2022.10.005"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2017.07.001"},{"key":"e_1_2_11_26_1","first-page":"1","article-title":"Characterization of Skin Barrier Defects Using Infrared Spectroscopy in Patients With Atopic Dermatitis","volume":"00","author":"Williams S. 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