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Despite their importance, the shared and distinct features of VECs across various inflammatory skin conditions remain poorly understood. We analysed single\u2010cell data from 94 skin samples, encompassing healthy individuals and patients with psoriasis, atopic dermatitis, and lupus erythematosus and established a comprehensive VEC atlas spanning multiple inflammatory skin diseases. Our results highlight both common and disease\u2010specific features of VECs, particularly in immune cell activation, angiogenesis, metabolic processes, and intercellular communication. Notably, post\u2010capillary VECs (cluster P) emerged as the most activated subpopulation, exhibiting significant enrichment in pro\u2010inflammatory signalling pathways. Interestingly, cluster P showed distinct pseudotemporal relationships with different VEC clusters across different inflammatory conditions, suggesting disease\u2010specific transcriptional state transitions. Besides, VECs employ both disease\u2010specific ligand\u2013receptor networks to recruit immune cells and remodel stromal niches, alongside conserved mechanisms preserving vascular\u2010immune crosstalk across pathologies. Our study provides a detailed characterisation of VEC pathology in various forms of skin inflammation and offers novel insights into the role of vascular biology in the pathogenesis of skin diseases.<\/jats:p>","DOI":"10.1111\/exd.70195","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T07:51:03Z","timestamp":1766044263000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross Disease Single\u2010Cell Meta\u2010Analysis Deciphers Conserved Pan\u2010Inflammatory Circuits and Divergent Endothelial Rewiring in Inflammatory Skin Pathogenesis"],"prefix":"10.1111","volume":"34","author":[{"given":"Jiaxin","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Xijing Hospital Fourth Military Medical University  Shaanxi 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