{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T16:12:50Z","timestamp":1789488770793,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073471"],"award-info":[{"award-number":["82073471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acne and hidradenitis suppurativa (HS) are inflammatory disorders of the pilosebaceous unit that exhibit distinct clinical manifestations, indicating that they likely differ in their underlying pathophysiology. Microbial dysbiosis is implicated in both diseases, yet direct comparisons using unified methods and analyses incorporating the oral microbiome are lacking. In this study, we collected lesional and nonlesional skin, buccal mucosa and faecal samples from 28 HS patients, 29 acne patients and 40 healthy controls, and profiled microbial communities using 16S rRNA V3\u2013V4 sequencing with qPCR validation. HS lesions showed a pronounced enrichment of anaerobic Gram\u2010negative taxa, including\n                    <jats:italic>Prevotella<\/jats:italic>\n                    ,\n                    <jats:italic>Porphyromonas<\/jats:italic>\n                    and\n                    <jats:italic>Fusobacterium<\/jats:italic>\n                    , whereas acne lesions were dominated by\n                    <jats:italic>Cutibacterium<\/jats:italic>\n                    and\n                    <jats:italic>Pseudomonas<\/jats:italic>\n                    . Oral microbiome diversity was increased in both diseases, with HS showing distinct enrichment of Prevotella and Veillonella. HS patients also exhibited reduced gut microbial diversity. Correlation analyses revealed coordinated microbial alterations across the oral\u2013gut\u2013skin axis, and qPCR confirmed elevated concentrations of key anaerobes in HS. By directly comparing acne and HS across multiple anatomical sites, our study helps differentiate general inflammatory microbiome changes from those more specific to HS. The findings also suggest a potential oral\u2013gut\u2013skin microbial axis that may contribute to the chronic and destructive phenotype of HS, providing insights that could inform future microbiome\u2010targeted therapeutic approaches.\n                  <\/jats:p>","DOI":"10.1111\/exd.70198","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:29:35Z","timestamp":1767169775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dysbiosis in Acne Vulgaris and Hidradenitis Suppurativa: A Comparative Microbiome Analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2054-8464","authenticated-orcid":false,"given":"Wanxin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8472-9637","authenticated-orcid":false,"given":"Xin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8141-7244","authenticated-orcid":false,"given":"Qian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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