{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:09:18Z","timestamp":1792012158998,"version":"4.4.0"},"reference-count":116,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hidradenitis suppurativa (HS) is an autoinflammatory skin disease characterised by deep\u2010seated and painful nodules, abscesses and draining tunnels that extensively penetrate the dermis in the axillae, inguinal and gluteal areas. The exact aetiology remains unclear. However, current evidence suggests that HS originates from an intrinsic defect within the hair follicle, leading to follicular obstruction, cyst development and eventual rupture, which triggers an inflammatory reaction. The initiation, progression and maintenance of the disease may involve functional abnormalities in keratinocytes (KCs), significantly contributing to the production of proinflammatory cytokines within and around the affected tissue and increased infiltration of immune cells. This review synthesises current evidence on KCs in HS, emphasising their genetic background and metabolic dysregulation. It comprehensively evaluates the cytokine milieu influenced by KCs within affected tissues. Notably, it highlights the diverse phenotypes of KCs within draining tunnels, underscoring their heterogeneity and implications for disease progression.<\/jats:p>","DOI":"10.1111\/exd.70200","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:35:43Z","timestamp":1768977343000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Roles of Keratinocytes in the Initiation, Progression and Maintenance of Hidradenitis Suppurativa"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7991-2237","authenticated-orcid":false,"given":"Xiaodong","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-3659","authenticated-orcid":false,"given":"Chong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-1538","authenticated-orcid":false,"given":"Yan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Dermatology Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19435"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000204"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0149-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14398"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.08.089"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.01.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00280"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdin.2020.05.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18445"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.12.651"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.05.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2315096120"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljac096"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.036"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI131180"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.02.003"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17779"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14214"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.11.018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.05.027"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512455"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.01.023"},{"key":"e_1_2_11_24_1","first-page":"2039","article-title":"Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the Disease","volume":"10","author":"Moltrasio C.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196284"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.07.020"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14223"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18460"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13906"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2021.05.022"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000525526"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11684-019-0722-8"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12098"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1916645117"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci169225"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282763"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191284198"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13978"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90667"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17111"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16000"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2021.06.007"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.21.11872"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2023.2217"},{"key":"e_1_2_11_45_1","doi-asserted-by":"crossref","unstructured":"M.Marohn M.\u2010J.Lin W.\u2010W.Yu et\u00a0al. \u201cDefining Epidermal Stem Cell Fate Infidelity and Immunogenicity in Hidradenitis Suppurativa at the Single\u2010Cell Resolution \u201d bioRxiv (2020) https:\/\/doi.org\/10.1101\/2020.04.21.053611.","DOI":"10.1101\/2020.04.21.053611"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2005.06.064"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.233247.113"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.153488"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.04.021"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12105"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000521263"},{"key":"e_1_2_11_52_1","doi-asserted-by":"crossref","unstructured":"C. M.Smith B.Moran A.Zabarowski et\u00a0al. \u201cSingle\u2010Cell Transcriptomic Profiling of Hyperproliferative Keratinocytes in Hidradenitis Suppurativa \u201dhttps:\/\/doi.org\/10.26226\/morressier.6170a2077c09fc044a97428e.","DOI":"10.26226\/morressier.6170a2077c09fc044a97428e"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.18465"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00915.x"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1995.tb02624.x"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517017"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.01.059"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.03.016"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.011"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101371"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24108854"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.07.187"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.139932"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20097"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000512617"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18983"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13919"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19795"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228436"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)02475-9"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2023.11.004"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1769-5"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14389"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16019"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-019-02012-w"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci144336"},{"key":"e_1_2_11_77_1","article-title":"Proof\u2010of\u2010Concept Study Exploring the Effect of Spesolimab in Patients With Moderate\u2010to\u2010Severe Hidradenitis Suppurativa: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Clinical Trial","volume":"5","author":"Alavi A.","year":"2024","journal-title":"British Journal of Dermatology"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15961"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18556"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjd\/ljad273"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01620-3"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.10.020"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13449"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.05.033"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01655-6"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1186455"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00101-6"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00591-9"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111691"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20750"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14433"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001240"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2020.108375"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13482"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10765.x"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510689"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16320"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02970.x"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10225320"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19462"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.10.030"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15424"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.20642"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16147"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18309"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.02.742"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903907"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.21060"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa124"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12234"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13232"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2004.00166.x"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14036"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.07.005"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xjidi.2025.100350"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169870"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12233"}],"container-title":["Experimental Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/exd.70200","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/exd.70200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:43:12Z","timestamp":1789486992000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/exd.70200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":116,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/exd.70200"],"URL":"https:\/\/doi.org\/10.1111\/exd.70200","archive":["Portico"],"relation":{},"ISSN":["0906-6705","1600-0625"],"issn-type":[{"value":"0906-6705","type":"print"},{"value":"1600-0625","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-08-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70200"}}