{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:05:52Z","timestamp":1789679152464,"version":"4.0.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T00:00:00Z","timestamp":1768521600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["108\u2010CGN12"],"award-info":[{"award-number":["108\u2010CGN12"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Experimental Dermatology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The gut microbiota composition of patients with chronic spontaneous urticaria (CSU) has been shown to be different from that of healthy controls. However, whether the gut microbiome is different between CSU patients with different treatment responses to omalizumab is seldom examined and is largely unknown. Antihistamine\u2010refractory CSU patients were enrolled to receive three injections of omalizumab. The patients were divided into two groups based on their treatment responses to omalizumab determined using the weekly urticarial activity score. Demographic data, blood samples and faecal specimens were collected before, during and after omalizumab treatment. Faecal specimens underwent bacterial 16S ribosomal RNA sequencing to determine the gut bacterial microbiome. Serum biomarkers were examined using enzyme\u2010linked immunosorbent assay. Fourteen patients were enrolled and were divided into two groups: complete responders (CRs) and non\u2010complete responders (NCRs). At baseline, the \u03b1\u2010diversity indices of the CR group were higher than those of the NCR group. The bacterial microbiota composition was different between the groups, but these differences became less obvious after omalizumab treatment. At baseline, the genera\n                    <jats:italic>Bacteroides<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ,\n                    <jats:italic>Prevotella_9<\/jats:italic>\n                    ,\n                    <jats:italic>Butyricimonas<\/jats:italic>\n                    ,\n                    <jats:italic>Dialister<\/jats:italic>\n                    ,\n                    <jats:italic>Megasphaera<\/jats:italic>\n                    and\n                    <jats:italic>Ruminococcaceae_UCG\u2010002<\/jats:italic>\n                    were more abundant in the CR group. In addition, the changes in the IL\u201033 and IL\u201017 levels after omalizumab treatment were correlated with the changes in the relative abundances of\n                    <jats:italic>Dialister<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u20090.929,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003) and\n                    <jats:italic>Ruminococcaceae\u2010UCG\u2010002<\/jats:italic>\n                    (\n                    <jats:italic>r<\/jats:italic>\n                    \u2009=\u2009\u22120.828,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.022), respectively. In conclusion, the CR patients' distinct and characteristic gut bacterial microbiota profile before treatment may contribute to their better responses to omalizumab.\n                  <\/jats:p>","DOI":"10.1111\/exd.70208","type":"journal-article","created":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:50:26Z","timestamp":1768625426000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinct Gut Microbiome Signatures of Complete Responders to Omalizumab in Chronic Spontaneous Urticaria"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5297-8997","authenticated-orcid":false,"given":"Yung\u2010Tsu","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Yu","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02496.x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.07.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13397"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13357"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19561"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.13209"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2023.05.003"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.12.809"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12870"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S184986"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12549"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-41149-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13786"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-017-0178-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6417471"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2017.05.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13010152"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000653"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44373-x"},{"key":"e_1_2_11_22_1","first-page":"A16","article-title":"Gut\u2010Skin Axis: Decoding the Link Between the Gut Microbiome and Hives","volume":"69","author":"Lee L. 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